Evidence map›Paper›PMID 34946153›Full record

ArticleMicroorganisms2021

The Unusual Lipid A Structure and Immunoinhibitory Activity of LPS from Marine Bacteria

Molly Dorothy Pither, Giuseppe Mantova, Elena Scaglione, Chiara Pagliuca, Roberta Colicchio, Mariateresa Vitiello, Oleg V Chernikov, Kuo-Feng Hua, Maxim S Kokoulin, Alba Silipo and 3 more

Open access · goldAbstract read
In one paragraph

Article in Microorganisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. LPS in gram-negative bacterial growth and physiology: outside but fully integrated.Microbiology and molecular biology reviews : MMBR · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Molly Dorothy PitherDepartment of Chemical Sciences, University of Naples Federico II, Via Cinthia 4, 80126 Naples, Italy.
Giuseppe MantovaDepartment of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Via S. Pansini n 5, 80131 Naples, Italy.
Elena ScaglioneDepartment of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Via S. Pansini n 5, 80131 Naples, Italy.
Chiara PagliucaDepartment of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Via S. Pansini n 5, 80131 Naples, Italy.ORCID 0000-0003-1704-6606
Roberta ColicchioDepartment of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Via S. Pansini n 5, 80131 Naples, Italy.ORCID 0000-0002-4861-5085
Mariateresa VitielloDepartment of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Via S. Pansini n 5, 80131 Naples, Italy.
Oleg V ChernikovG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, 159/2, Prospect 100 Let Vladivostoku, 690022 Vladivostok, Russia.ORCID 0000-0002-3076-3637
Kuo-Feng HuaDepartment of Biotechnology and Animal Science, National Ilan University, No. 1, Sec. 1, Shen-Lung Road, Ilan 26099, Taiwan.
Maxim S KokoulinG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, 159/2, Prospect 100 Let Vladivostoku, 690022 Vladivostok, Russia.ORCID 0000-0003-2245-6802
Alba SilipoDepartment of Chemical Sciences, University of Naples Federico II, Via Cinthia 4, 80126 Naples, Italy.ORCID 0000-0002-5394-6532
Paola SalvatoreDepartment of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Via S. Pansini n 5, 80131 Naples, Italy.
Antonio MolinaroDepartment of Chemical Sciences, University of Naples Federico II, Via Cinthia 4, 80126 Naples, Italy.
Flaviana Di LorenzoTask Force on Microbiome Studies, University of Naples Federico II, 80126 Naples, Italy.
University of Naples Federico II · ITPacific Institute of Bioorganic Chemistry. GB Elyakova Far Eastern Branch of the Russian Academy of Sciences · RUCeinge Biotecnologie Avanzate (Italy) · ITNational Ilan University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gram-negative bacteria experiencing marine habitats are constantly exposed to stressful conditions dictating their survival and proliferation. In response to these selective pressures, marine microorganisms adapt their membrane system to ensure protection and dynamicity in order to face the highly mutable sea environments. As an integral part of the Gram-negative outer membrane, structural modifications are commonly observed in the lipopolysaccharide (LPS) molecule; these mainly involve its glycolipid portion, i.e., the lipid A, mostly with regard to fatty acid content, to counterbalance the alterations caused by chemical and physical agents. As a consequence, unusual structural chemical features are frequently encountered in the lipid A of marine bacteria. By a combination of data attained from chemical, MALDI-TOF mass spectrometry (MS), and MS/MS analyses, here, we describe the structural characterization of the lipid A isolated from two marine bacteria of the

Indexed as

Echinicolalipid Alipopolysaccharide (LPS)marine bacteriastructural characterizationTLR4 antagonists

Identifiers

PMID34946153
PMCPMC8707317
OpenAlexW4200229281

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.