Evidence map›Paper›PMID 34946152›Full record

ReviewMicroorganisms2021

Advances in Biosynthesis of Natural Products from Marine Microorganisms.

Quan Zhou, Kinya Hotta, Yaming Deng, Rui Yuan, Shu Quan, Xi Chen

Open access · goldAbstract readReview
In one paragraph

Review in Microorganisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 32 citations in OpenAlex.

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  16. Genomic study and lipidomic bioassay ofFrontiers in microbiology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Quan ZhouKey Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an 710127, China.ORCID 0000-0002-1196-0803
Kinya HottaGenetech Biotechnology Pte Ltd., 8 Temasek Boulevard #34-03, Singapore 038988, Singapore.ORCID 0000-0002-9427-0081
Yaming DengKey Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an 710127, China.
Rui YuanKey Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an 710127, China.
Shu QuanState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai Collaborative Innovation Center for Biomanufacturing (SCICB), 130 Meilong Rd., Shanghai 200237, China.ORCID 0000-0002-6672-4947
Xi ChenKey Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an 710127, China.ORCID 0000-0001-8295-2854
Ministry of Education of the People's Republic of China · CNEast China University of Science and Technology · CN

Funding

National Natural Science Foundation of China 21807088Open Funding Project of the State Key Laboratory of Bioreactor Engineering 2018OPEN05Project Program of the State Key Tumor Biology Laboratory CBSKL2019KF07Projects of International Cooperation in Shaanxi Province of China 2020KW-060
6 · The paper itself

Abstract

Natural products play an important role in drug development, among which marine natural products are an underexplored resource. This review summarizes recent developments in marine natural product research, with an emphasis on compound discovery and production methods. Traditionally, novel compounds with useful biological activities have been identified through the chromatographic separation of crude extracts. New genome sequencing and bioinformatics technologies have enabled the identification of natural product biosynthetic gene clusters in marine microbes that are difficult to culture. Subsequently, heterologous expression and combinatorial biosynthesis have been used to produce natural products and their analogs. This review examines recent examples of such new strategies and technologies for the development of marine natural products.

Indexed as

combinatorial biosynthesisgenomic screeningheterologous expressionmarine natural products

Identifiers

PMID34946152
PMCPMC8706298
OpenAlexW4200588528

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.