Evidence map›Paper›PMID 34946054›Full record

ArticleMicroorganisms2021

Clinical and Functional Predictors of Response to a Comprehensive Pulmonary Rehabilitation in Severe Post-COVID-19 Patients.

Marc Spielmanns, Melissa Masha Buelow, Anna Maria Pekacka-Egli, Mikis Cecon, Sabine Spielmanns, Wolfram Windisch, Matthias Hermann

Registry-linked trialAbstract read
In one paragraph

Article in Microorganisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05736939 (Gender Differences in the Recovery Rate Following a Hybrid Pulmonary Rehabilitation Programme in Patients With Long COVID-19 Syndrome), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05736939 completednot on this mapstarted 2022, after this paper: background citation

Gender Differences in the Recovery Rate Following a Hybrid Pulmonary Rehabilitation Programme in Patients With Long COVID-19 Syndrome

TypeobservationalSponsorNational and Kapodistrian University of AthensRan2022 to 2023Enrolled30ConditionsPost Acute COVID-19 SyndromeArmsOut-patient Pulmonary Rehabilitation
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marc SpielmannsPulmonary Medicine and Sleep Medicine Center, Zurich RehaCenter Klinik Wald, CH-8636 Wald, Switzerland.ORCID 0000-0003-4541-6977
Melissa Masha BuelowPulmonary Medicine and Sleep Medicine Center, Zurich RehaCenter Klinik Wald, CH-8636 Wald, Switzerland.
Anna Maria Pekacka-EgliPulmonary Medicine and Sleep Medicine Center, Zurich RehaCenter Klinik Wald, CH-8636 Wald, Switzerland.
Mikis CeconPulmonary Medicine and Sleep Medicine Center, Zurich RehaCenter Klinik Wald, CH-8636 Wald, Switzerland.
Sabine SpielmannsPulmonary Medicine and Sleep Medicine Center, Zurich RehaCenter Klinik Wald, CH-8636 Wald, Switzerland.
Wolfram WindischDepartment of Pulmonary Medicine, Faculty of Health, University Witten-Herdecke, D-58455 Witten, Germany.ORCID 0000-0001-7574-2672
Matthias HermannDepartment of Cardiology, University Heart Centre, University Hospital Zurich, CH-8006 Zurich, Switzerland.ORCID 0000-0002-0694-7719

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPulmonary rehabilitation (PR) following severe and very severe COVID-19 infection is known to be effective, according to typical assessments. However, not all patients benefit from PR to the same extent. This analysis aimed to identify the impact of different factors on PR outcomes in post-COVID-19 patients.

methodsThis prospective observational study included 184 post-COVID-19 patients. The achievement of the predicted reference walking distance (6 min walking distance (6-MWD)) served as a parameter with which to identify responders and non-responders to PR. Several parameters (e.g., Functional Independent Measurement (FIM); pulmonary function testing (Forced Vital Capacity, FVC); 6MWD) were assessed in order to estimate their impact on PR success. Logistic regression models and classification and regression trees were used for multivariate analysis.

resultsA total of 94 patients (51%) reached their reference 6MWD by the end of PR. FVC (0.95 (0.93-0.97)), 6MWD at admission (0.99 (0.99-1.00)), and FIM motoric (0.96 (0.93-0.99)) correlated with the risk not reaching the reference distance. The most important variable was the 6MWD at admission. Classification and regression tree identified 6MWD ≥ 130 m at admission and FVC predicted of >83% as the strongest predictor for reaching predicted 6-MWD.

conclusionPost-COVID-19 patients with lower 6MWD, lower motoric FIM scores and lower FVC at admission have a high risk of not reaching their target values of physical performance despite intensive rehabilitation. As well as identifying them, it is of utmost importance to develop optimal PR concepts for these patients.

Indexed as

6-MWDCOVID-19FIMFVCpulmonary rehabilitation

Identifiers

PMID34946054
PMCPMC8708417

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.