Evidence map›Paper›PMID 34946050›Full record

ArticleMicroorganisms2021

Developing a Live Probiotic Vaccine Based on the

Yulia Desheva, Galina Leontieva, Tatiana Kramskaya, Tatiana Gupalova, Igor Losev, Eugenia Kuleshevich, Elena Bormotova, Olga Kopteva, Polina Kudar, Alexander Suvorov

Open access · goldAbstract read
In one paragraph

Article in Microorganisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Scientific Basics of Personalized Medicine: Realities and Opportunities.Herald of the Russian Academy of Sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Yulia DeshevaScientific and Educational Center "Molecular Bases of Interaction of Microorganisms and Human" of the World-Class Research Center "Center for Personalized Medicine" FSBSI "IEM", 197376 Saint Petersburg, Russia.ORCID 0000-0001-9794-3520
Galina LeontievaScientific and Educational Center "Molecular Bases of Interaction of Microorganisms and Human" of the World-Class Research Center "Center for Personalized Medicine" FSBSI "IEM", 197376 Saint Petersburg, Russia.
Tatiana KramskayaScientific and Educational Center "Molecular Bases of Interaction of Microorganisms and Human" of the World-Class Research Center "Center for Personalized Medicine" FSBSI "IEM", 197376 Saint Petersburg, Russia.
Tatiana GupalovaScientific and Educational Center "Molecular Bases of Interaction of Microorganisms and Human" of the World-Class Research Center "Center for Personalized Medicine" FSBSI "IEM", 197376 Saint Petersburg, Russia.ORCID 0000-0002-4824-3621
Igor LosevScientific and Educational Center "Molecular Bases of Interaction of Microorganisms and Human" of the World-Class Research Center "Center for Personalized Medicine" FSBSI "IEM", 197376 Saint Petersburg, Russia.ORCID 0000-0002-5245-7315
Eugenia KuleshevichScientific and Educational Center "Molecular Bases of Interaction of Microorganisms and Human" of the World-Class Research Center "Center for Personalized Medicine" FSBSI "IEM", 197376 Saint Petersburg, Russia.
Elena BormotovaScientific and Educational Center "Molecular Bases of Interaction of Microorganisms and Human" of the World-Class Research Center "Center for Personalized Medicine" FSBSI "IEM", 197376 Saint Petersburg, Russia.
Olga KoptevaScientific and Educational Center "Molecular Bases of Interaction of Microorganisms and Human" of the World-Class Research Center "Center for Personalized Medicine" FSBSI "IEM", 197376 Saint Petersburg, Russia.
Polina KudarScientific and Educational Center "Molecular Bases of Interaction of Microorganisms and Human" of the World-Class Research Center "Center for Personalized Medicine" FSBSI "IEM", 197376 Saint Petersburg, Russia.
Alexander SuvorovScientific and Educational Center "Molecular Bases of Interaction of Microorganisms and Human" of the World-Class Research Center "Center for Personalized Medicine" FSBSI "IEM", 197376 Saint Petersburg, Russia.
Institute of Experimental Medicine · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Probiotic microorganisms are currently considered as a promising platform for the development of recombinant vaccines expressing foreign antigens. In this study, we generated and evaluated the live mucosal recombinant vaccine by integrating genes encoding influenza virus neuraminidase (NA) of the N2 subtype into the DNA of the probiotic strain

Indexed as

E. faecium L3influenza neuraminidaselive mucosal vaccineprobiotic microorganism

Identifiers

PMID34946050
PMCPMC8707194
OpenAlexW3214958272

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.