Evidence map›Paper›PMID 34945839›Full record

ArticleJournal of personalized medicine2021

Chronic Kidney Disease and Its Relationship with Mental Health: Allostatic Load Perspective for Integrated Care.

Federica Guerra, Dina Di Giacomo, Jessica Ranieri, Marilena Tunno, Luca Piscitani, Claudio Ferri

Open access · goldAbstract read
In one paragraph

Article in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 37 citations in OpenAlex.

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  12. Weight Management Experiences Among People With CKD: A Qualitative Study.Canadian journal of kidney health and disease · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Federica GuerraDepartment Mesva, University of L'Aquila, 67100 L'Aquila, AQ, Italy.ORCID 0000-0002-7652-8229
Dina Di GiacomoDepartment Mesva, University of L'Aquila, 67100 L'Aquila, AQ, Italy.ORCID 0000-0001-8189-2052
Jessica RanieriDepartment Mesva, University of L'Aquila, 67100 L'Aquila, AQ, Italy.ORCID 0000-0002-5222-3447
Marilena TunnoDyalisis Division, San Salvatore Hospital of L'Aquila, 67100 L'Aquila, AQ, Italy.
Luca PiscitaniDyalisis Division, San Salvatore Hospital of L'Aquila, 67100 L'Aquila, AQ, Italy.
Claudio FerriDepartment Mesva, University of L'Aquila, 67100 L'Aquila, AQ, Italy.
University of L'Aquila · ITSan Salvatore Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic renal failure is a chronic medical condition characterized by a progressive and irreversible loss of kidney function. Up to 50% of patients undergoing dialysis experience symptoms of depression and anxiety: what is the impact of individual factors and medical conditions on the mental health issue? The present study was carried out to investigate the individual factors (biomarkers and psychological dimensions) of end-stage renal disease patients dealing with dialysis, analyzing their predictor values for developing negative disease adaptations by an allostatic paradigm.

methodsWe conducted an observational study on 35 patients affected by end-stage renal disease; biological and psychological markers have been detected. We conducted descriptive statistical analyses (

resultsThe findings showed a positive correlation between creatinine levels and psychological distress as well as stress index. No significant effect of "time of dialysis", "time from diagnosis", "age" and "personality traits" was found.

conclusionOur findings showed that personality traits did not represent a protective factor by moderating positive emotional adaptations; conversely, creatinine levels appeared predictive for negative emotional adaptations. High levels of creatinine were found to be positively associated with high stress levels as well psychological distress. According to the allostatic paradigm, end-stage renal disease patients could experience an allostatic load and more overload towards poor health outcomes; integrated biological and psychological measurements could prevent increased negative mental health through a patient-centered approach.

Indexed as

allostatic loadanxietybiomarkerscreatininedepressionend-stage renal diseasepsychological dimensionspsychological distressstress

Identifiers

PMID34945839
PMCPMC8705378
OpenAlexW4200236915

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.