Evidence map›Paper›PMID 34945821›Full record

ReviewJournal of personalized medicine2021

Towards Multimodal Machine Learning Prediction of Individual Cognitive Evolution in Multiple Sclerosis.

Stijn Denissen, Oliver Y Chén, Johan De Mey, Maarten De Vos, Jeroen Van Schependom, Diana Maria Sima, Guy Nagels

Open access · goldAbstract readReview
In one paragraph

Review in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Machine Learning in Clinical Trials: A Primer with Applications to Neurology.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
    Review
  8. Article
  9. Review
  10. Personalized Diagnosis and Therapy for Multiple Sclerosis.Journal of personalized medicine · 2022
    Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Stijn DenissenAIMS Laboratory, Center for Neurosciences, UZ Brussel, Vrije Universiteit Brussel, 1050 Brussels, Belgium.ORCID 0000-0003-2852-5530
Oliver Y ChénFaculty of Social Sciences and Law, University of Bristol, Bristol BS8 1QU, UK.
Johan De MeyAIMS Laboratory, Center for Neurosciences, UZ Brussel, Vrije Universiteit Brussel, 1050 Brussels, Belgium.
Maarten De VosFaculty of Engineering Science, KU Leuven, 3001 Leuven, Belgium.
Jeroen Van SchependomAIMS Laboratory, Center for Neurosciences, UZ Brussel, Vrije Universiteit Brussel, 1050 Brussels, Belgium.
Diana Maria SimaAIMS Laboratory, Center for Neurosciences, UZ Brussel, Vrije Universiteit Brussel, 1050 Brussels, Belgium.ORCID 0000-0002-0118-2905
Guy NagelsAIMS Laboratory, Center for Neurosciences, UZ Brussel, Vrije Universiteit Brussel, 1050 Brussels, Belgium.
Vrije Universiteit Brussel · BEKU Leuven · BEUniversity of Bristol · GB

Funding

Flanders Innovation and Entrepreneurship HBC.2019.2579Research Foundation - Flanders 1805620N
6 · The paper itself

Abstract

Multiple sclerosis (MS) manifests heterogeneously among persons suffering from it, making its disease course highly challenging to predict. At present, prognosis mostly relies on biomarkers that are unable to predict disease course on an individual level. Machine learning is a promising technique, both in terms of its ability to combine multimodal data and through the capability of making personalized predictions. However, most investigations on machine learning for prognosis in MS were geared towards predicting physical deterioration, while cognitive deterioration, although prevalent and burdensome, remained largely overlooked. This review aims to boost the field of machine learning for cognitive prognosis in MS by means of an introduction to machine learning and its pitfalls, an overview of important elements for study design, and an overview of the current literature on cognitive prognosis in MS using machine learning. Furthermore, the review discusses new trends in the field of machine learning that might be adopted for future studies in the field.

Indexed as

artificial intelligencecognitionmachine learningmultiple sclerosisprognosis

Identifiers

PMID34945821
PMCPMC8707909
OpenAlexW4200305004

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.