ArticleJournal of personalized medicine2021
Dysregulated Notch Signaling in the Airway Epithelium of Children with Wheeze.
Article in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Conservation of gene expression patterns between the amniotic and nasal epithelium at birth.ERJ open research · 2025Article
- Single-cell profiling demonstrates the combined effect of wheeze phenotype and infant viral infection on airway epithelial development.Science advances · 2025Article
- Notch Signaling Pathway Interfering as a Possible Asthma Treatment: A Narrative Review.Journal of asthma and allergy · 2025Review
- How early life respiratory viral infections impact airway epithelial development and may lead to asthma.Frontiers in pediatrics · 2024Review
- The influence of modern living conditions on the human microbiome and potential therapeutic opportunities for allergy prevention.The World Allergy Organization journal · 2024Review
- Airway epithelium respiratory illnesses and allergy (AERIAL) birth cohort: study protocol.Frontiers in allergy · 2024Article
- Network analyses of upper and lower airway transcriptomes identify shared mechanisms among children with recurrent wheezing and school-age asthma.Frontiers in immunology · 2023Article
Corrections and comments
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Authors and funding
17 authors at 3 institutions in 2 countries.
Funding
Abstract
The airway epithelium of children with wheeze is characterized by defective repair that contributes to disease pathobiology. Dysregulation of developmental processes controlled by Notch has been identified in chronic asthma. However, its role in airway epithelial cells of young children with wheeze, particularly during repair, is yet to be determined. We hypothesized that Notch is dysregulated in primary airway epithelial cells (pAEC) of children with wheeze contributing to defective repair. This study investigated transcriptional and protein expression and function of Notch in pAEC isolated from children with and without wheeze. Primary AEC of children with and without wheeze were found to express all known Notch receptors and ligands, although pAEC from children with wheeze expressed significantly lower
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.