ArticleJournal of personalized medicine2021
Genomic Characterization of Host Factors Related to SARS-CoV-2 Infection in People with Dementia and Control Populations: The GR@ACE/DEGESCO Study.
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Article in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Lack of association between APOE genotypes and COVID-19 in a black South African cohort.Scientific reports · 2026Article
- The physiological effects of APOE genotype in healthy young/middle-aged individuals.Biological reviews of the Cambridge Philosophical Society · 2026Article
- Host Genetic Variants Linked to COVID-19 Neurological Complications and Susceptibility in Young Adults-A Preliminary Analysis.Journal of personalized medicine · 2023Article
- Increased mRNA Levels ofBiomedicines · 2022Article
- APOE interacts with ACE2 inhibiting SARS-CoV-2 cellular entry and inflammation in COVID-19 patients.Signal transduction and targeted therapy · 2022Article
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Authors and funding
55 authors at 16 institutions in 3 countries.
Itziar de RojasResearch Center and Memory Clinic, Ace Alzheimer Center Barcelona-Universitat Internacional de Catalunya, 08017 Barcelona, Spain.ORCID 0000-0002-2148-381X
Isabel HernándezResearch Center and Memory Clinic, Ace Alzheimer Center Barcelona-Universitat Internacional de Catalunya, 08017 Barcelona, Spain.
Laura MontrrealResearch Center and Memory Clinic, Ace Alzheimer Center Barcelona-Universitat Internacional de Catalunya, 08017 Barcelona, Spain.
Inés QuintelaGrupo de Medicina Xenómica, Centro Nacional de Genotipado (CEGEN-PRB3-ISCIII), Universidade de Santiago de Compostela, 15705 Santiago de Compostela, Spain.
Miguel CaleroCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, 28220 Madrid, Spain.ORCID 0000-0001-5366-3324
Jose Luís RoyoDepatamento de Especialidades Quirúrgicas, Bioquímica e Inmunología, Facultad de Medicina, Universidad de Málaga, 29016 Málaga, Spain.
Raquel Huerto VilasUnitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, 25198 Lleida, Spain.
Antonio González-PérezCAEBI, Centro Andaluz de Estudios Bioinformáticos, 41013 Sevilla, Spain.
Emilio Franco-MacíasUnidad de Demencias, Servicio de Neurología y Neurofisiología, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, 41013 Sevilla, Spain.
Juan MacíasUnidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, 41013 Sevilla, Spain.
Manuel Menéndez-GonzálezServicio de Neurología, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain.ORCID 0000-0002-5218-0774
Ana Frank-GarcíaCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, 28220 Madrid, Spain.
Mónica Diez-FairenFundació Docència i Recerca MútuaTerrassa, 08221 Terrassa, Spain.ORCID 0000-0003-1882-0309
Carmen LageCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, 28220 Madrid, Spain.
Sebastián García-MadronaHospital Universitario Ramon y Cajal, IRYCIS, 28034 Madrid, Spain.
Nuria AguileraResearch Center and Memory Clinic, Ace Alzheimer Center Barcelona-Universitat Internacional de Catalunya, 08017 Barcelona, Spain.
Pablo García-GonzálezResearch Center and Memory Clinic, Ace Alzheimer Center Barcelona-Universitat Internacional de Catalunya, 08017 Barcelona, Spain.
Raquel PuertaResearch Center and Memory Clinic, Ace Alzheimer Center Barcelona-Universitat Internacional de Catalunya, 08017 Barcelona, Spain.
Oscar Sotolongo-GrauResearch Center and Memory Clinic, Ace Alzheimer Center Barcelona-Universitat Internacional de Catalunya, 08017 Barcelona, Spain.
Silvia Alonso-LanaResearch Center and Memory Clinic, Ace Alzheimer Center Barcelona-Universitat Internacional de Catalunya, 08017 Barcelona, Spain.
Alberto RábanoCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, 28220 Madrid, Spain.ORCID 0000-0001-9320-6566
Alfonso Arias PastorUnitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, 25198 Lleida, Spain.
Ana Belén PastorCIEN Foundation/Queen Sofia Foundation Alzheimer Center, 28220 Madrid, Spain.
Anaïs Corma-GómezUnidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, 41013 Sevilla, Spain.
Angel Martín MontesCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, 28220 Madrid, Spain.
Carmen Martínez RodríguezInstituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33011 Asturias, Spain.
Dolores Buiza-RuedaCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, 28220 Madrid, Spain.
Maria Teresa PeriñánCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, 28220 Madrid, Spain.
Eloy Rodriguez-RodriguezCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, 28220 Madrid, Spain.ORCID 0000-0001-7742-677X
Ignacio AlvarezFundació Docència i Recerca MútuaTerrassa, 08221 Terrassa, Spain.ORCID 0000-0002-8537-3935
Irene Rosas AllendeInstituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33011 Asturias, Spain.
Juan A PinedaUnidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, 41013 Sevilla, Spain.
María Bernal Sánchez-ArjonaUnidad de Demencias, Servicio de Neurología y Neurofisiología, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, 41013 Sevilla, Spain.
Marta Fernández-FuertesUnidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, 41013 Sevilla, Spain.
Silvia MendozaAlzheimer Research Center & Memory Clinic, Andalusian Institute for Neuroscience, 29012 Málaga, Spain.
Teodoro Del SerDepartment of Neurology/CIEN Foundation/Queen Sofia Foundation Alzheimer Center, 28220 Madrid, Spain.
Gr Ace/Degesco Consortium
Guillermo Garcia-RibasHospital Universitario Ramon y Cajal, IRYCIS, 28034 Madrid, Spain.
Pascual Sánchez-JuanCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, 28220 Madrid, Spain.
Pau PastorFundació Docència i Recerca MútuaTerrassa, 08221 Terrassa, Spain.
María J BullidoCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, 28220 Madrid, Spain.ORCID 0000-0002-6477-1117
Victoria ÁlvarezInstituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33011 Asturias, Spain.ORCID 0000-0002-1916-2523
Luis M RealUnidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, 41013 Sevilla, Spain.ORCID 0000-0003-4932-7429
Pablo MirCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, 28220 Madrid, Spain.
Gerard Piñol-RipollUnitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, 25198 Lleida, Spain.
Jose María García-AlbercaCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, 28220 Madrid, Spain.
Miguel MedinaCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, 28220 Madrid, Spain.ORCID 0000-0002-7016-5340
Adelina OrellanaResearch Center and Memory Clinic, Ace Alzheimer Center Barcelona-Universitat Internacional de Catalunya, 08017 Barcelona, Spain.
Chris R ButlerResearch Center and Memory Clinic, Ace Alzheimer Center Barcelona-Universitat Internacional de Catalunya, 08017 Barcelona, Spain.ORCID 0000-0002-7502-9284
Marta MarquiéResearch Center and Memory Clinic, Ace Alzheimer Center Barcelona-Universitat Internacional de Catalunya, 08017 Barcelona, Spain.
María Eugenia SáezCAEBI, Centro Andaluz de Estudios Bioinformáticos, 41013 Sevilla, Spain.ORCID 0000-0001-9299-2534
Ángel CarracedoGrupo de Medicina Xenómica, Centro Nacional de Genotipado (CEGEN-PRB3-ISCIII), Universidade de Santiago de Compostela, 15705 Santiago de Compostela, Spain.ORCID 0000-0003-1085-8986
Lluís TárragaResearch Center and Memory Clinic, Ace Alzheimer Center Barcelona-Universitat Internacional de Catalunya, 08017 Barcelona, Spain.
Mercè BoadaResearch Center and Memory Clinic, Ace Alzheimer Center Barcelona-Universitat Internacional de Catalunya, 08017 Barcelona, Spain.
Agustín RuizResearch Center and Memory Clinic, Ace Alzheimer Center Barcelona-Universitat Internacional de Catalunya, 08017 Barcelona, Spain.ORCID 0000-0003-2633-2495
Instituto de Salud Carlos III · ESFundació ACE · ESHospital Universitario de Valme · ESHospital Universitari de Santa Maria · ESUniversidad de Cantabria · ESUniversity Hospital Mútua de Terrassa · ESCentro Andaluz de Biología del Desarrollo · ESHospital Universitario Central de Asturias · ESInstituto de Biomedicina de Sevilla · ESInstituto Ramón y Cajal de Investigación Sanitaria · ESUniversidade de Santiago de Compostela · ESFundacion Centro De Investigacion De Enfermedades Neurologicas · ESHospital Universitario De Cabueñes · ESPontificia Universidad Católica de Chile · CLUniversidad de Málaga · ESUniversidad de Oviedo · ES
Funding
Grifols SA, Fundación bancaria 'La Caixa', Fundació ACE, and CIBERNED NAMedical Research Council MR/K010395/1Queen Sofia Foundation and the Instituto de Salud Carlos III NA
Abstract
Emerging studies have suggested several chromosomal regions as potential host genetic factors involved in the susceptibility to SARS-CoV-2 infection and disease outcome. We nested a COVID-19 genome-wide association study using the GR@ACE/DEGESCO study, searching for susceptibility factors associated with COVID-19 disease. To this end, we compared 221 COVID-19 confirmed cases with 17,035 individuals in whom the COVID-19 disease status was unknown. Then, we performed a meta-analysis with the publicly available data from the COVID-19 Host Genetics Initiative. Because the
Indexed as
APOECOVID-19dementiaGR@ACE/DEGESCOGWASSARS-CoV-2
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.