Evidence map›Paper›PMID 34945752›Full record

ArticleJournal of personalized medicine2021

Telomere Length and Arterial Stiffness Reflected by Brachial-Ankle Pulse Wave Velocity: A Population-Based Cross-Sectional Study.

Kyi Mar Wai, Sawada Kaori, Ken Itoh, Okuyama Shinya, Yuka Uchikawa, Sakura Hayashi, Akiko Shiraki, Koichi Murashita, Shigeyuki Nakaji, Kazushige Ihara

Open access · goldAbstract read
In one paragraph

Article in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Observational
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Kyi Mar WaiDepartment of Social Medicine, Graduate School of Medicine, Hirosaki University, Hirosaki 036-8562, Japan.ORCID 0000-0001-8755-277X
Sawada KaoriDepartment of Social Medicine, Graduate School of Medicine, Hirosaki University, Hirosaki 036-8562, Japan.
Ken ItohCenter of Advanced Medical Science, Department of Stress Response Science, Graduate School of Medicine, Hirosaki University, Hirosaki 036-8562, Japan.ORCID 0000-0002-5518-0729
Okuyama ShinyaDepartment of Social Medicine, Graduate School of Medicine, Hirosaki University, Hirosaki 036-8562, Japan.
Yuka UchikawaResearch and Development Division, MiRTeL Company Limited, Hiroshima 734-0001, Japan.
Sakura HayashiBusiness Development Division, MiRTeL Company Limited, Hiroshima 734-0001, Japan.ORCID 0000-0002-8708-8767
Akiko ShirakiInspection Division, MiRTeL Company Limited, Hiroshima 734-0001, Japan.
Koichi MurashitaCenter of Innovation, Research Initiatives Organization, Hirosaki University, Hirosaki 036-8562, Japan.
Shigeyuki NakajiDepartment of Social Medicine, Graduate School of Medicine, Hirosaki University, Hirosaki 036-8562, Japan.ORCID 0000-0002-4190-5151
Kazushige IharaDepartment of Social Medicine, Graduate School of Medicine, Hirosaki University, Hirosaki 036-8562, Japan.
Hirosaki University · JP

Funding

Japan Science and Technology Agency JMPJCE1302
6 · The paper itself

Abstract

Telomere (TL) is a biomarker of biological aging, and its shortening is associated with major risk factors for cardiovascular diseases (CVD). This study aimed to identify whether TL is associated with arterial stiffness as reflected by brachial-ankle pulse wave velocity (baPWV). This population-based cross-sectional study involved 1065 individuals in the Iwaki area, Japan. Total TL length and TL G-tail length were measured by hybridization protection assay. The baPWV was measured on the right and left sides using a non-invasive vascular screening device. The associations between TL and baPWV were assessed by multivariate linear regression. Compared with the shortest total TL tertile, the longest total TL group showed a significant decrease in baPWV (lowest vs. highest tertile: adjusted beta: -41.24, 95% confidence interval (CI): -76.81, -5.68). The mean baPWV decreased with a longer TL (TL G-tail length:

Indexed as

arterial stiffnessG-tail lengthJapanpulse wave velocitytelomere

Identifiers

PMID34945752
PMCPMC8704522
OpenAlexW3217256810

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.