ReviewJournal of personalized medicine2021
Perioperative Magnesium for Postoperative Analgesia: An Umbrella Review of Systematic Reviews and Updated Meta-Analysis of Randomized Controlled Trials.
Review in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Pooled it
- The effects of magnesium sulfate added to epidurally administered local anesthetic on postoperative pain: a systematic review.Brazilian journal of anesthesiology (Elsevier)Pooled it
- Sequence-Dependent Analgesic Efficacy of Ketamine and Magnesium Sulfate After Radical Nephrectomy.Medicina (Kaunas, Lithuania) · 2026Trial
- The Effect of Oral Magnesium Supplement on Postoperative Pain Following Mandibular Third Molar Surgery: A Split-Mouth Randomized Placebo-Controlled Trial.Pain research & management · 2025Trial
- Effect of Intravenous Magnesium on Postoperative Pain and Analgesic Outcomes in Patients Undergoing General Anesthesia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Mapping the Neuroprotective Landscape of Perioperative Magnesium Sulphate: A Translational Scoping Review.Journal of clinical medicine · 2026Review
- Magnesium Sulfate as an Adjuvant to Local Anesthetic in Erector Spinae Plane Block: A Systematic Review of Randomized Controlled Trials.Life (Basel, Switzerland) · 2026Review
- Personalized Multimodal and Opioid-Sparing Analgesia for Postoperative Pain Management: Enhancing Recovery and Addressing the Post-Discharge Gap.Journal of pain research · 2026Review
- Application and translational research of magnesium in nursing care of orthopedic diseases: from mechanism to clinical translation.Frontiers in chemistry · 2026Review
- Magnesium Sulfate as an Analgesic and Sedative-sparing Agent in Patients under Mechanical Ventilation: A Randomized, Double Blind Clinical Trial.Journal of research in pharmacy practice · 2026Article
- Comparison of Succinylcholine, Rocuronium, and Rocuronium with Magnesium on Time of Onset of Paralysis in Adult Patients Undergoing Rapid Sequence Induction: A Double Blinded Randomised Control Trial.Turkish journal of anaesthesiology and reanimation · 2025Article
- Clinical Efficacy of Magnesium in Perioperative Pain Management: A Narrative Review.Current pain and headache reports · 2025Review
- Optimal Dose of Magnesium Sulfate Infusion in Obese Patients: A Double-Blind Randomized Trial.Anesthesiology research and practice · 2025Article
- Acute pain management in patients with severe obesity.BJA education · 2024Review
- Optimizing patient-controlled analgesia: a narrative review based on a single center audit process.Anesthesia and pain medicine · 2024Review
- Methadone in combination with magnesium, ketamine, lidocaine, and dexmedetomidine improves postoperative outcomes after coronary artery bypass grafting: an observational multicentre study.Journal of cardiothoracic surgery · 2024Observational
- Introduction to Umbrella Reviews as a Useful Evidence-Based Practice.Journal of lipid and atherosclerosis · 2023Review
- Acute Pain Management Pearls: A Focused Review for the Hospital Clinician.Healthcare (Basel, Switzerland) · 2022Review
- Strategy for Calculating Magnesium Sulfate Dose in Obese Patients: A Randomized Blinded Trial.Anesthesiology research and practice · 2022Article
- Intraoperative Analgesia with Magnesium Sulfate versus Remifentanil Guided by Plethysmographic Stress Index in Post-Bariatric Dermolipectomy: A Randomized Study.Anesthesiology research and practice · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The purpose of this study was to summarize and evaluate evidence on the effectiveness of perioperative magnesium as an adjuvant for postoperative analgesia. We conducted an umbrella review of the evidence across systematic reviews and meta-analyses of randomized controlled trials (RCTs) on the effect of perioperative magnesium on pain after surgical procedures. Two independent investigators retrieved pain-related outcomes and assessed the methodological quality of the evidence of included studies using the A MeaSurement Tool to Assess systematic Reviews (AMSTAR) tool, and the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system. In addition, an updated meta-analysis of postoperative pain-related outcomes with a trial sequential analysis (TSA) was conducted. Of the 773 articles initially identified, 17 systematic reviews and meta-analyses of 258 RCTs were included in the current umbrella review. Based on the AMSTAR tool, the overall confidence of the included systematic reviews was deemed critically low to low. Pain score, analgesic consumption, time to first analgesic request, and incidence of analgesic request were examined as pain-related outcomes. According to the GRADE system, the overall quality of evidence ranged from very low to moderate. While the updated meta-analysis showed the beneficial effect of perioperative magnesium on postoperative analgesia, and TSA appeared to suggest sufficient existing evidence, the heterogeneity was substantial for every outcome. Although the majority of included systematic reviews and updated meta-analysis showed a significant improvement in outcomes related to pain after surgery when magnesium was administered during the perioperative period, the evidence reveals a limited confidence in the beneficial effect of perioperative magnesium on postoperative pain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.