Evidence map›Paper›PMID 34945712›Full record

ArticleJournal of personalized medicine2021

miR-335-laden B Cell-Derived Extracellular Vesicles Promote SOX4-Dependent Apoptosis in Human Multiple Myeloma Cells.

Elisabetta Lombardi, Gonzalo Almanza, Kinga Kowal, Marco Valvasori, Francesco Agostini, Carla Vicinanza, Francesco Da Ros, Cristina Durante, Miriam Marangon, Mariagrazia Michieli and 3 more

Open access · goldAbstract read
In one paragraph

Article in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Elisabetta LombardiStem Cell Unit, Department of Research and Advance Cancer Diagnostic, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, 33081 Aviano, Italy.ORCID 0000-0002-3688-9281
Gonzalo AlmanzaThe Laboratory of Immunology, Department of Medicine and Moores Cancer Center, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 2093-0815, USA.
Kinga KowalStem Cell Unit, Department of Research and Advance Cancer Diagnostic, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, 33081 Aviano, Italy.ORCID 0000-0002-1041-3111
Marco ValvasoriStem Cell Unit, Department of Research and Advance Cancer Diagnostic, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, 33081 Aviano, Italy.
Francesco AgostiniStem Cell Unit, Department of Research and Advance Cancer Diagnostic, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, 33081 Aviano, Italy.ORCID 0000-0002-2808-9348
Carla VicinanzaStem Cell Unit, Department of Research and Advance Cancer Diagnostic, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, 33081 Aviano, Italy.
Francesco Da RosStem Cell Unit, Department of Research and Advance Cancer Diagnostic, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, 33081 Aviano, Italy.
Cristina DuranteStem Cell Unit, Department of Research and Advance Cancer Diagnostic, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, 33081 Aviano, Italy.
Miriam MarangonStem Cell Unit, Department of Research and Advance Cancer Diagnostic, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, 33081 Aviano, Italy.
Mariagrazia MichieliOncohematology and Cell Therapy Unit, Department of Medical Oncology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, 33081 Aviano, Italy.
Maurizio RupoloOncohematology and Cell Therapy Unit, Department of Medical Oncology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, 33081 Aviano, Italy.ORCID 0000-0001-7932-2827
Mario MazzucatoStem Cell Unit, Department of Research and Advance Cancer Diagnostic, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, 33081 Aviano, Italy.ORCID 0000-0001-8319-053X
Maurizio ZanettiThe Laboratory of Immunology, Department of Medicine and Moores Cancer Center, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 2093-0815, USA.ORCID 0000-0001-6346-8776
Centro di Riferimento Oncologico · ITUniversity of California San Diego · USUniversity of Trieste · IT

Funding

Alleanza Contro il Cancro J34I20000600001CRO intramural grant E8841100359000finchè ci siete voi ci sono anche io I31I170007
6 · The paper itself

Abstract

Multiple myeloma (MM) is characterized by the accumulation of malignant plasma cells in the bone marrow. Despite novel therapies, MM still remains an incurable cancer and new strategies are needed. Increased expression of the transcription factor Sex-determining region Y-related high-mobility-group box transcription factor 4 (

Indexed as

exosomesgene therapymiR-335multiple myeloma (MM)SOX4

Identifiers

PMID34945712
PMCPMC8707697
OpenAlexW3214949482

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.