ArticleFoods (Basel, Switzerland)2021
Ultra-Processed Food Impairs Bone Quality, Increases Marrow Adiposity and Alters Gut Microbiome in Mice.
Article in Foods (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 27 citations in OpenAlex.
- Associations of ultra-processed food intake with bone mineral density and fractures in the UK Biobank.The British journal of nutrition · 2026Article
- Higher consumption of ultra-processed foods is associated with increased risk of fracture among adults: findings from China Health and Nutrition Survey.European journal of nutrition · 2026Article
- The Impact of Modern Lifestyles on Spinal Health in the Pediatric Population: A Narrative Review.Children (Basel, Switzerland) · 2026Review
- Too easy to swallow.Nature medicine · 2025Article
- Impacts of non-nutritive sweeteners on the human microbiome.Immunometabolism (Cobham, Surrey) · 2025Review
- Ultra-Processed Food and Its Impact on Bone Health and Joint Diseases: A Scoping Review.Nutrients · 2025Article
- Gut microbiota in multiple sclerosis and animal models.The FEBS journal · 2025Review
- Exploring the relationship between ultra-processed food consumption and gut microbiota at school age in a Brazilian birth cohort.Cadernos de saude publica · 2025Article
- Adiposity and Mineral Balance in Chronic Kidney Disease.Current osteoporosis reports · 2024Review
- Article
- Ultra-processed foods and food additives in gut health and disease.Nature reviews. Gastroenterology & hepatology · 2024Review
- Eating away cancer: the potential of diet and the microbiome for shaping immunotherapy outcome.Frontiers in immunology · 2024Review
- Effects of ultra-processed foods on the liver: insights from gut microbiome and metabolomics studies in rats.Frontiers in nutrition · 2024Article
- Higher ultra processed foods intake is associated with low muscle mass in young to middle-aged adults: a cross-sectional NHANES study.Frontiers in nutrition · 2024Article
- Mmp2 Deficiency Leads to Defective Parturition and High Dystocia Rates in Mice.International journal of molecular sciences · 2023Article
- Ultra-processed foods in a rural Ecuadorian community: associations with child anthropometry and bone maturation.The British journal of nutrition · 2023Article
- Effect of milk fat globules on growth and metabolism in rats fed an unbalanced diet.Frontiers in nutrition · 2023Article
- Revisiting Protein Quality Assessment to Include Alternative Proteins.Foods (Basel, Switzerland) · 2022Article
- The Use of Post-Natal Skeleton Development as Sensitive Preclinical Model to Test the Quality of Alternative Protein Sources in the Diet.Nutrients · 2022Article
- Associations of ultra-processed food intake with maternal weight change and cardiometabolic health and infant growth.The international journal of behavioral nutrition and physical activity · 2022Observational
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Ultra processed foods (UPF) consumption is becoming dominant in the global food system, to the point of being the most recent cause of malnutrition. Health outcomes of this diet include obesity and metabolic syndrome; however, its effect on skeletal development has yet to be examined. This project studied the influence of UPF diet on the development and quality of the post-natal skeleton. Young female mice were fed with regular chow diet, UPF diet, UPF diet supplemented with calcium or with multivitamin and mineral complex. Mice fed UPF diet presented unfavorable morphological parameters, evaluated by micro-CT, alongside inferior mechanical performance of the femora, evaluated by three-point bending tests. Growth-plate histology evaluation suggested a modification of the growth pattern. Accumulation of adipose tissue within the bone marrow was significantly higher in the group fed UPF diet. Finally, microbiome 16SrRNA sequencing was used to explore the connection between diets, gut microbial community and skeletal development. Together, we show that consumption of UPF diet during the postnatal developmental period alters the microbiome and has negative outcomes on bone parameters and bone marrow adiposity. Micronutrients improved these phenotypes only partially. Thus, consuming a wholesome diet that contributes to a healthy microbiota is of a great significance in order to achieve healthy skeletal development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.