Evidence map›Paper›PMID 34945431›Full record

ArticleMicromachines2021

Nanoribbon Biosensor in the Detection of miRNAs Associated with Colorectal Cancer.

Yuri D Ivanov, Kristina V Goldaeva, Kristina A Malsagova, Tatyana O Pleshakova, Rafael A Galiullin, Vladimir P Popov, Nikolay E Kushlinskii, Alexander A Alferov, Dmitry V Enikeev, Natalia V Potoldykova and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Micromachines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yuri D IvanovLaboratory of Nanobiotechnology, Institute of Biomedical Chemistry, 119121 Moscow, Russia.
Kristina V GoldaevaLaboratory of Nanobiotechnology, Institute of Biomedical Chemistry, 119121 Moscow, Russia.ORCID 0000-0002-4082-1247
Kristina A MalsagovaLaboratory of Nanobiotechnology, Institute of Biomedical Chemistry, 119121 Moscow, Russia.ORCID 0000-0001-9404-1660
Tatyana O PleshakovaLaboratory of Nanobiotechnology, Institute of Biomedical Chemistry, 119121 Moscow, Russia.
Rafael A GaliullinLaboratory of Nanobiotechnology, Institute of Biomedical Chemistry, 119121 Moscow, Russia.
Vladimir P PopovRzhanov Institute of Semiconductor Physics, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.ORCID 0000-0002-7415-1405
Nikolay E KushlinskiiN.N. Blokhin National Medical Research Center of Oncology, 115478 Moscow, Russia.ORCID 0000-0002-3898-4127
Alexander A AlferovN.N. Blokhin National Medical Research Center of Oncology, 115478 Moscow, Russia.
Dmitry V EnikeevInstitute of Urology and Reproductive Health, Sechenov University, 119992 Moscow, Russia.
Natalia V PotoldykovaInstitute of Urology and Reproductive Health, Sechenov University, 119992 Moscow, Russia.
Alexander I ArchakovLaboratory of Nanobiotechnology, Institute of Biomedical Chemistry, 119121 Moscow, Russia.

Funding

The Ministry of Education and Science of the Russian Federation Agreement No. 075-15-2021-993, unique project ID: RF00121X0004
6 · The paper itself

Abstract

A nanoribbon biosensor (NRBS) was developed to register synthetic DNAs that simulate and are analogous to miRNA-17-3p associated with colorectal cancer. Using this nanoribbon biosensor, the ability to detect miRNA-17-3p in the blood plasma of a patient diagnosed with colorectal cancer has been demonstrated. The sensing element of the NRBS was a nanochip based on a silicon-on-insulator (SOI) nanostructure. The nanochip included an array of 10 nanoribbons and was designed with the implementation of top-down technology. For biospecific recognition of miRNA-17-3p, the nanochip was modified with DNA probes specific for miRNA-17-3p. The performance of the nanochip was preliminarily tested on model DNA oligonucleotides, which are synthetic analogues of miRNA-17-3p, and a detection limit of ~10

Indexed as

cancercolorectal cancermiRNAnanoribbonnanoribbon biosensorsilicon-on-insulator

Identifiers

PMID34945431
PMCPMC8705149

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.