Evidence map›Paper›PMID 34945319›Full record

ArticleMicromachines2021

Biocompatibility Study of a Commercial Printed Circuit Board for Biomedical Applications: Lab-on-PCB for Organotypic Retina Cultures.

Jesús David Urbano-Gámez, Lourdes Valdés-Sánchez, Carmen Aracil, Berta de la Cerda, Francisco Perdigones, Álvaro Plaza Reyes, Francisco J Díaz-Corrales, Isabel Relimpio López, José Manuel Quero

Abstract read
In one paragraph

Article in Micromachines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jesús David Urbano-GámezElectronic Technology Group, Department of Electronic Engineering, Higher Technical School of Engineering, University of Seville, Avda. de los Descubrimientos sn, 41092 Seville, Spain.
Lourdes Valdés-SánchezDepartment of Regeneration and Cell Therapy, Andalusian Molecular Biology and Regenerative Medicine Centre (CABIMER), Avda. Américo Vespucio 24, 41092 Seville, Spain.ORCID 0000-0001-9385-3915
Carmen AracilElectronic Technology Group, Department of Electronic Engineering, Higher Technical School of Engineering, University of Seville, Avda. de los Descubrimientos sn, 41092 Seville, Spain.ORCID 0000-0003-2589-5114
Berta de la CerdaDepartment of Regeneration and Cell Therapy, Andalusian Molecular Biology and Regenerative Medicine Centre (CABIMER), Avda. Américo Vespucio 24, 41092 Seville, Spain.ORCID 0000-0001-5603-6473
Francisco PerdigonesElectronic Technology Group, Department of Electronic Engineering, Higher Technical School of Engineering, University of Seville, Avda. de los Descubrimientos sn, 41092 Seville, Spain.ORCID 0000-0002-3996-8970
Álvaro Plaza ReyesDepartment of Regeneration and Cell Therapy, Andalusian Molecular Biology and Regenerative Medicine Centre (CABIMER), Avda. Américo Vespucio 24, 41092 Seville, Spain.ORCID 0000-0003-1167-6316
Francisco J Díaz-CorralesDepartment of Regeneration and Cell Therapy, Andalusian Molecular Biology and Regenerative Medicine Centre (CABIMER), Avda. Américo Vespucio 24, 41092 Seville, Spain.ORCID 0000-0002-5752-0205
Isabel Relimpio LópezRETICS Oftared, Carlos III Institute of Health (Spain), Ministry of Health RD16/0008/0010, University Hospital Virgen Macarena, Avda. Dr. Fedriani, 3, 41009 Seville, Spain.
José Manuel QueroElectronic Technology Group, Department of Electronic Engineering, Higher Technical School of Engineering, University of Seville, Avda. de los Descubrimientos sn, 41092 Seville, Spain.ORCID 0000-0002-3905-2874

Funding

Regional Government of Andalusia Proyectos I+D+i FEDER Andalucía 2014-2020, US-1265983
6 · The paper itself

Abstract

Printed circuit board (PCB) technology is well known, reliable, and low-cost, and its application to biomedicine, which implies the integration of microfluidics and electronics, has led to Lab-on-PCB. However, the biocompatibility of the involved materials has to be examined if they are in contact with biological elements. In this paper, the solder mask (PSR-2000 CD02G/CA-25 CD01, Taiyo Ink (Suzhou) Co., Ltd., Suzhou, China) of a commercial PCB has been studied for retinal cultures. For this purpose, retinal explants have been cultured over this substrate, both on open and closed systems, with successful results. Cell viability data shows that the solder mask has no cytotoxic effect on the culture allowing the application of PCB as the substrate of customized microelectrode arrays (MEAs). Finally, a comparative study of the biocompatibility of the 3D printer Uniz zSG amber resin has also been carried out.

Indexed as

biomedical applicationsLab-on-PCBorganotypic cultureprinted circuit board

Identifiers

PMID34945319
PMCPMC8707730

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.