Evidence map›Paper›PMID 34945274›Full record

ArticleJournal of clinical medicine2021

The Utility of Metabolic Parameters on Baseline F-18 FDG PET/CT in Predicting Treatment Response and Survival in Paediatric and Adolescent Hodgkin Lymphoma.

Janet Denise Reed, Andries Masenge, Ane Buchner, Fareed Omar, David Reynders, Mariza Vorster, Christophe Van de Wiele, Mike Sathekge

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Journal of cancer research and clinical oncology · 2025
    Article
  4. [Asia Oceania journal of nuclear medicine & biology · 2025
    Article
  5. Clinical scoring systems, molecular subtypes and baseline [Cancer imaging : the official publication of the International Cancer Imaging Society · 2024
    Review
  6. Recent advancements inAmerican journal of nuclear medicine and molecular imaging · 2024
    Review
  7. Clinical value ofFrontiers in oncology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Janet Denise ReedDepartment of Nuclear Medicine, University of Pretoria, Pretoria 0002, South Africa.
Andries MasengeDepartment of Statistics, University of Pretoria, Pretoria 0002, South Africa.
Ane BuchnerSteve Biko Academic Hospital, Pretoria 0002, South Africa.
Fareed OmarSteve Biko Academic Hospital, Pretoria 0002, South Africa.
David ReyndersSteve Biko Academic Hospital, Pretoria 0002, South Africa.
Mariza VorsterDepartment of Nuclear Medicine, University of Pretoria, Pretoria 0002, South Africa.
Christophe Van de WieleDepartment of Radiology and Nuclear Medicine, University of Ghent, 9000 Ghent, Belgium.
Mike SathekgeDepartment of Nuclear Medicine, University of Pretoria, Pretoria 0002, South Africa.ORCID 0000-0002-2806-0625
Steve Biko Hospital · ZAUniversity of Pretoria · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lymphoma is the third most common paediatric cancer. Early detection of high-risk patients is necessary to anticipate those who require intensive therapy and follow-up. Current literature shows that residual tumor avidity on PET (Positron Emission Tomography) following chemotherapy corresponds with decreased survival. However, the value of metabolic parameters has not been adequately investigated. In this retrospective study, we aimed to evaluate the prognostic value of metabolic and other parameters in paediatric and adolescent Hodgkin lymphoma. We recorded tMTV (total Metabolic Tumor Volume), TLG (Total Lesion Glycolysis), and SUVmax (maximum Standard Uptake Value) on baseline PET, as well the presence of bone marrow or visceral involvement. HIV (human immunodeficiency virus) status and baseline biochemistry from clinical records were noted. All patients received stage-specific standard of care therapy. Response assessment on end-of-treatment PET was evaluated according to the Deauville criteria. We found that bone marrow involvement (

Indexed as

F-18 FDG PET/CT (fluoro-deoxy-glucose positron emission tomography/computed tomography)Hodgkin lymphoma (HL)human immunodeficiency virus (HIV)maximum standard uptake value (SUVmax)metabolic parametersoverall survival (OS)paediatric oncologyprogression-free survival (PFS)total lesion glycolysis (TLG)total metabolic tumor volume (tMTV)

Identifiers

PMID34945274
PMCPMC8706037
OpenAlexW4200438558

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.