ArticleJournal of clinical medicine2021
Headache Worsening after COVID-19 Vaccination: An Online Questionnaire-Based Study on 841 Patients with Migraine.
Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Potential association of cluster headache with certain COVID-19 vaccines: An assessment from the pharmacovigilance databases.Headache · 2026Article
- Patterns of Past COVID-19 and EBV Infection in Primary Headache Disorders: A Population Study.Brain and behavior · 2025Article
- A retrospective cohort study: is COVID-19 BNT162b2 mRNA vaccination a trigger factor for cluster headache?Acta neurologica Belgica · 2024Article
- Effects of vaccination on COVID-19 infection symptoms in multiple sclerosis patients.eNeurologicalSci · 2024Article
- Occurrence of new or more severe headaches following COVID-19 is associated with markers of microglial activation and peripheral sensitization: results from a prospective cohort study.The journal of headache and pain · 2024Article
- Review
- Questionnaire-based study of COVID-19 vaccination induced headache: evidence of clusters of adverse events.BMC neurology · 2024Article
- Health equity, care access and quality in headache - part 1.The journal of headache and pain · 2024Review
- Article
- COVID-19 vaccination-related headache showed two different clusters in the long-term course: a prospective multicenter follow-up study (COVA-Head Study).The journal of headache and pain · 2023Observational
- [Headache associated with COVID-19 vaccination: how to classify?]Schmerz (Berlin, Germany) · 2023Article
- COVID-19 and SARS-CoV-2 Vaccines: A Cameo Role for Headache.International journal of environmental research and public health · 2023Article
- Characteristics of headaches attributed to SARS-CoV-2 vaccination and factors associated with its frequency and prolongation: a cross-sectional cohort study.Frontiers in neurology · 2023Article
- Headache After Vaccination: An Update on Recent Clinical Trials and Real-World Reporting.Current pain and headache reports · 2022Review
- NeuroCOVID-19: a critical review.Arquivos de neuro-psiquiatria · 2022Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vaccines have represented the breakthrough in the fight against COVID-19. Based on reported headache attacks after vaccination in randomized controlled trials, we focused on the effects of COVID-19 vaccine administration on the migraine population, using an online questionnaire published on Italian Facebook groups oriented to headache patients. We collected data about the demographics and clinical parameters of migraine severity, COVID-19 infection, vaccination, and characteristics of headaches following vaccination. Out of 841 migraine patients filling in the questionnaire, 66.47% and 60.15% patients experienced a headache attack (from 1 hour to 7 days) after the first and the second vaccine dose, respectively. The main finding concerns headaches perceived by 57.60% of patients: attacks following vaccination were referred to as more severe (50.62% of patients), long-lasting (52.80% of patients) and hardwearing (49.69% of patients) compared to the usually experienced migraine attacks. This could be related to the production of inflammatory mediators such as type Iβ interferon. Considering the high prevalence of migraine in the general population, awareness of the possibility of headaches worsening following COVID-19 vaccination in these patients may allow both patients and clinicians to face this clinical entity with conscious serenity, and to reduce the waste of resources towards inappropriate health-care.
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