Evidence map›Paper›PMID 34945203›Full record

ReviewJournal of clinical medicine2021

Recent Advances on the Role and Therapeutic Potential of Regulatory T Cells in Atherosclerosis.

Toru Tanaka, Naoto Sasaki, Yoshiyuki Rikitake

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

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  7. Depletion of Foxp3Heliyon · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Toru TanakaLaboratory of Medical Pharmaceutics, Kobe Pharmaceutical University, Kobe 658-8558, Japan.
Naoto SasakiLaboratory of Medical Pharmaceutics, Kobe Pharmaceutical University, Kobe 658-8558, Japan.
Yoshiyuki RikitakeLaboratory of Medical Pharmaceutics, Kobe Pharmaceutical University, Kobe 658-8558, Japan.ORCID 0000-0001-7207-4656
Kobe Pharmaceutical University · JP

Funding

JSPS KAKENHI 23790849, 25860601, 15K09156, and 18K08088
6 · The paper itself

Abstract

Atherosclerotic diseases, including ischemic heart disease and stroke, are a main cause of mortality worldwide. Chronic vascular inflammation via immune dysregulation is critically involved in the pathogenesis of atherosclerosis. Accumulating evidence suggests that regulatory T cells (Tregs), responsible for maintaining immunological tolerance and suppressing excessive immune responses, play an important role in preventing the development and progression of atherosclerosis through the regulation of pathogenic immunoinflammatory responses. Several strategies to prevent and treat atherosclerosis through the promotion of regulatory immune responses have been developed, and could be clinically applied for the treatment of atherosclerotic cardiovascular disease. In this review, we summarize recent advances in our understanding of the protective role of Tregs in atherosclerosis and discuss attractive approaches to treat atherosclerotic disease by augmenting regulatory immune responses.

Indexed as

atherosclerosisimmunologyinflammationregulatory T cells

Identifiers

PMID34945203
PMCPMC8707380
OpenAlexW4200187777

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.