ReviewJournal of clinical medicine2021
Tuberculosis in the Elderly.
Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
103 citing papers in PubMed, 2 syntheses or guidelines pooled it, 148 citations in OpenAlex.
- Outcomes of endobronchial ultrasound-transbronchial needle aspiration in elderly patients: A systematic review and meta-analysis.Journal of medical ultrasonics (2001) · 2025Pooled it
- The asymptomatic tuberculosis proportion among the elderly population: a systematic review and meta-analysis.BMC public health · 2024Pooled it
- Unexpected doornail hilar lymph nodes during robot-assisted pulmonary resection: intraoperative challenges and management strategies.Journal of robotic surgery · 2026Article
- Characterizing Tuberculosis Medication Side Effects Using Video Directly Observed Therapy Monitoring in Uganda: Opportunities for Digital Pharmacovigilance.Research square · 2026Article
- Tuberculosis Development in Chronic Obstructive Pulmonary Disease: A Nationwide Population-Based Study.Journal of Korean medical science · 2026Article
- Development and validation of machine-learning diagnostic models for identifying frailty in older adults with tuberculosis: a multicentre observational study protocol.BMC pulmonary medicine · 2026Observational
- Tuberculosis incidence trends and risk factors among people living with human immunodeficiency virus (HIV) in Sichuan, China: a retrospective cohort study (2010-2024).BMC infectious diseases · 2026Article
- Elimination of senescent cells with senolytic drugs as adjunctive host-directed therapy reduces tuberculosis progression in mice.Nature communications · 2026Article
- Epidemiology of geriatric tuberculosis: a five-year retrospective study from a tertiary care hospital in India.BMC geriatrics · 2026Article
- Targeting immunosenescence in lung diseases: mechanistic insights and clinical interventions.BMC medicine · 2026Review
- Article
- Factors associated with the willingness to accept tuberculosis preventive treatment among close contacts in Yantai, China: a cross-sectional study.BMC public health · 2026Article
- Long-Term Trends and Determinants of Tuberculosis Burden in China, 1990-2023: Insights from the Global Burden of Disease Study 2023.Pathogens (Basel, Switzerland) · 2026Article
- Trends in Tuberculosis Incidence and Treatment Outcomes in Kazakhstan: A Decade of Observational Data.Tropical medicine and infectious disease · 2026Article
- Comparative tuberculosis risk in healthcare and educational workers: occupational synergy.ERJ open research · 2026Article
- Optimizing Quality of Care for Elderly Tuberculosis Patients in Shanghai, China: Insights from Patient Cascade of Care and Patient Pathway Analysis.Tropical medicine and infectious disease · 2026Article
- Tuberculosis Diagnostic Delays in Indonesian Primary Care Pathways.Annals of global health · 2026Observational
- From HIV to SARS-CoV-2 associated neurological disorder ("HAND" to "SAND"): Viral infection as a "time-bomb" for the aging brain.Neuroscience applied · 2026Review
- Association between laboratory-based frailty index and unfavorable treatment outcomes in older adults with drug-susceptible pulmonary tuberculosis in the Republic of Korea: a retrospective cohort study.Frontiers in public health · 2026Article
- Prediction of Tuberculosis Risk in the Elderly Population of Eastern China: Development and Validation of Multiple Machine Learning Models.Infection and drug resistance · 2026Article
43 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The tuberculosis (TB) epidemic is most prevalent in the elderly, and there is a progressive increase in the notification rate with age. Most cases of TB in the elderly are linked to the reactivation of lesions that have remained dormant. The awakening of these lesions is attributable to changes in the immune system related to senescence. The mortality rate from tuberculosis remains higher in elderly patients. Symptoms of active TB are nonspecific and less pronounced in the elderly. Diagnostic difficulties in the elderly are common in many diseases but it is important to use all possible techniques to make a microbiological diagnosis. Recognising frailty to prevent loss of independence is a major challenge in dealing with the therapeutic aspects of elderly patients. Several studies report contrasting data about poorer tolerance of TB drugs in this population. Adherence to antituberculosis treatment is a fundamental issue for the outcome of treatment. Decreased completeness of treatment was shown in older people as well as a higher risk of treatment failure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.