ArticleJournal of clinical medicine2021
Laparoscopic Isthmocele Repair: Efficacy and Benefits before and after Subsequent Cesarean Section.
Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Exploring uterine niche: a systemic review on secondary infertility rates, pathophysiological correlations, impact on assisted reproduction technology (ART), and the efficacy of surgical interventions.BMC pregnancy and childbirth · 2025Pooled it
- High live birth rates after laparoscopic isthmocele repair in infertility: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Cesarean Scar Defect (Isthmocele) and Secondary Infertility: A Systematic Review of Reproductive Significance.Cureus · 2026Review
- Isthmocele: from Detection to Treatment: A Narrative Review.Advances in therapy · 2026Review
- Post-Caesarean Huge Isthmocele with Multiple Endometriomas and Cervical Stenosis: Laparoscopic Excision and Repair.Journal of obstetrics and gynaecology of India · 2025Article
- Current surgical treatment of uterine isthmocele: an update of existing literature.Archives of gynecology and obstetrics · 2025Review
- Observational
- Analysis of outcomes of laparotomic, laparoscopic, and hysteroscopic symptomatic ısthmocele (niche) repair in Turkish women.Revista da Associacao Medica Brasileira (1992) · 2025Article
- Efficacy, Safety and Outcomes of the Laparoscopic Management of Cesarean Scar Ectopic Pregnancy as a Single Therapeutic Approach: A Case Series.Journal of clinical medicine · 2023Article
- Article
- Impact of Adenomyosis and Endometriosis on Chronic Pelvic Pain after Niche Repair.Journal of clinical medicine · 2023Article
- Laparoscopic Fluorescence Guided Detection of Uterine Niche-The Next Step in Surgical Diagnosis and Treatment.Journal of clinical medicine · 2022Article
- Endometriosis and Isthmocele: Common or Rare?Journal of clinical medicine · 2022Article
- Prevalence, definition, and etiology of cesarean scar defect and treatment of cesarean scar disorder: A narrative review.Reproductive medicine and biologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the effect of laparoscopic isthmocele repair on isthmocele-related symptoms and/or fertility-related problems. The residual myometrial thickness before and after subsequent cesarean section was also evaluated.
designRetrospective, case series.
settingPublic university hospital. POPULATION: Women with isthmocele (residual myometrium < 5 mm) complaining of abnormal uterine bleeding, chronic pelvic pain or secondary infertility not otherwise specified.
methodsWomen's complaints and the residual myometrium were assessed pre-operatively and at three to six months post-operatively. In patients who conceived after surgery, the latter was measured at least six months after delivery by cesarean section.
main outcome measuresResolution of the main symptom three to six months after surgery and persistence of laparoscopic repair benefits after subsequent cesarean section were considered as primary outcome measures.
resultsOverall, 31 women underwent laparoscopic isthmocele repair. The success rates of the surgery as improvement of abnormal uterine bleeding, chronic pelvic pain and secondary infertility were 71.4% (10 of 14), 83.3% (10 of 12) and 83.3% (10 of 12), respectively. Mean residual myometrial thickness increased significantly from 1.77 mm pre-operatively to 6.67 mm, three to six months post-operatively. Mean myometrial thickness in patients who underwent subsequent cesarean section (N = 7) was 4.49 mm. In this sub-group, there was no significant difference between the mean myometrial thickness measured after the laparoscopic isthmocele repair and that measured after the subsequent cesarean section. None of these patients reported recurrence of their symptoms after delivery.
conclusionOur findings suggest that the laparoscopic isthmocele excision and repair is an appropriate approach for the treatment of isthmocele-related symptoms when done by skilled laparoscopic surgeons. The benefit of this new surgical approach seems to persist even after a subsequent cesarean section. Further investigations and prospective studies are required to confirm this finding.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.