Evidence map›Paper›PMID 34945074›Full record

ArticleJournal of clinical medicine2021

Implications of Elevated Fibrosis-4 Index in Patients Receiving Trans-Catheter Aortic Valve Replacement.

Teruhiko Imamura, Nikhil Narang, Hiroshi Onoda, Shuhei Tanaka, Ryuichi Ushijima, Mitsuo Sobajima, Nobuyuki Fukuda, Hiroshi Ueno, Koichiro Kinugawa

Abstract read
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In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Teruhiko ImamuraThe Second Department of Internal Medicine, University of Toyama, Toyama 930-0194, Japan.ORCID 0000-0002-7294-7637
Nikhil NarangAdvocate Christ Medical Center, Chicago, IL 60453, USA.
Hiroshi OnodaThe Second Department of Internal Medicine, University of Toyama, Toyama 930-0194, Japan.
Shuhei TanakaThe Second Department of Internal Medicine, University of Toyama, Toyama 930-0194, Japan.ORCID 0000-0001-7551-3431
Ryuichi UshijimaThe Second Department of Internal Medicine, University of Toyama, Toyama 930-0194, Japan.
Mitsuo SobajimaThe Second Department of Internal Medicine, University of Toyama, Toyama 930-0194, Japan.
Nobuyuki FukudaThe Second Department of Internal Medicine, University of Toyama, Toyama 930-0194, Japan.
Hiroshi UenoThe Second Department of Internal Medicine, University of Toyama, Toyama 930-0194, Japan.ORCID 0000-0001-9747-2511
Koichiro KinugawaThe Second Department of Internal Medicine, University of Toyama, Toyama 930-0194, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe prognostic implication of the fibrosis-4 index, which represents the degree of hepatic injury, on patients receiving trans-catheter aortic valve replacement (TAVR) remains unknown.

methodsPatients who underwent TAVR to treat severe aortic stenosis at our institute between 2015 and 2020 were included in this retrospective study and followed for 2 years from the index discharge. The impact of the fibrosis-4 index, which was calculated using age, hepatic enzymes, and platelet count, on 2-year heart failure readmissions was investigated.

resultsA total of 272 patients (median age 85 (82, 88) years old, 76 (28%) men) were included. The median baseline fibrosis-4 index was 2.8 (2.2, 3.7). A high fibrosis-4 index (>3.79) was associated with higher cumulative incidence of the primary endpoint (18% versus 4%,

conclusionan elevated fibrosis-4 index at baseline, indicating the existence of persistent hepatic congestion, was associated with incidences of heart failure following TAVR. Calculating the fibrosis-4 index before TAVR is highly encouraged for risk stratification and shared decision making.

Indexed as

aortic valve diseasecongestionheart failurehemodynamics

Identifiers

PMID34945074
PMCPMC8705603

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.