Evidence map›Paper›PMID 34945065›Full record

ArticleJournal of clinical medicine2021

Redefining Remission Induction Chemotherapy Ineligibility by Early Mortality in De Novo Acute Myeloid Leukemia.

You-Cheng Li, Yu-Hsuan Shih, Tsung-Chih Chen, Jyh-Pyng Gau, Yu-Chen Su, Mei-Hui Chen, Chiann-Yi Hsu, Cai-Sian Liao, Chieh-Lin Jerry Teng

Abstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

You-Cheng LiDivision of Hematology/Medical Oncology, Department of Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan.
Yu-Hsuan ShihDivision of Hematology/Medical Oncology, Department of Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan.ORCID 0000-0002-4071-1670
Tsung-Chih ChenDivision of Hematology/Medical Oncology, Department of Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan.
Jyh-Pyng GauDivision of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei 40705, Taiwan.
Yu-Chen SuDivision of Hematology/Medical Oncology, Department of Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan.
Mei-Hui ChenDivision of Hematology/Medical Oncology, Department of Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan.ORCID 0000-0003-3528-2629
Chiann-Yi HsuBiostatistics Task Force, Taichung Veterans General Hospital, Taichung 40705, Taiwan.
Cai-Sian LiaoDepartment of Medical Research, Taichung Veterans General Hospital, Taichung 40705, Taiwan.
Chieh-Lin Jerry TengDivision of Hematology/Medical Oncology, Department of Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan.ORCID 0000-0001-9744-0368

Funding

Taichung Veterans General Hospital TCVGH-1103701C and TCVGH-1103701D
6 · The paper itself

Abstract

The therapeutic strategies for acute myeloid leukemia (AML) patients ineligible for remission induction chemotherapy have been improving in the past decade. Therefore, it is important to define ineligibility for remission induction chemotherapy. We retrospectively assessed 153 consecutive adult de novo AML patients undergoing remission induction chemotherapy and defined early mortality as death within the first 60 days of treatment. The 153 patients were stratified into the early mortality group (n = 29) and the non-early mortality group (n = 124). We identified potential factors to which early mortality could be attributed, investigated the cumulative incidence of early mortality for each aspect, and quantified the elements. The early mortality rate in our study cohort was 19.0%. Age ≥ 65 years (odds ratio (OR): 3.15; 95% confidence interval (CI): 1.05-9.44;

Indexed as

ageAMLearly mortalityLDHperformance status

Identifiers

PMID34945065
PMCPMC8708870

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.