ArticleJournal of clinical medicine2021
Potential Applications of Computational Fluid Dynamics for Predicting Hemolysis in Mitral Paravalvular Leaks.
Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Transcatheter Paravalvular Leak Closure: A Step-by-Step Guide.Journal of cardiovascular development and disease · 2026Review
- Effects of Shear and Extensional Stresses on Cells: Investigation in a Spiral Microchannel and Contraction-Expansion Arrays.ACS biomaterials science & engineering · 2025Review
- Statistical analysis of the measured strength parameters of the fresh main intracranial arteries.Frontiers in bioengineering and biotechnology · 2025Article
- Numerical validation of the applicability of the simplified ventricular model in the analysis of hemolysis in the mitral paravalvular leak.Frontiers in bioengineering and biotechnology · 2025Article
- In vivo fluid dynamics of the Ventura interatrial shunt device in patients with heart failure.ESC heart failure · 2024Article
- Prediction of Hemodynamic-Related Hemolysis in Carotid Stenosis and Aiding in Treatment Planning and Risk Stratification Using Computational Fluid Dynamics.Biomedicines · 2023Article
- Mitral Paravalvular Leak 3D Printing from 3D-Transesophageal Echocardiography.Anatolian journal of cardiology · 2023Article
- Parameters of Flow through Paravalvular Leak Channels from Computational Fluid Dynamics Simulations-Data from Real-Life Cases and Comparison with a Simplified Model.Journal of clinical medicine · 2022Article
- Quality of life after percutaneous paravalvular leak closure - a prospective registry.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Paravalvular leaks (PVLs) may lead to hemolysis. In vitro shear stress forces above 300 Pa cause erythrocyte destruction. PVL channel dimensions may determine magnitude of shear stress forces that affect erythrocytes; however, this has not been tested. It remains unclear how different properties of PVL channels contribute to presence of hemolysis. A model of a left ventricle was created based on data from computer tomography with Slicer software PVLs of various shapes and sizes were introduced. Blood flow was simulated using ANSYS Fluent software. The following variables were examined: wall shear stress, shear stress in fluid, volume of PVL channel with shear stress exceeding 300 Pa, and duration of exposure of erythrocytes to shear stress values above 300 Pa. In all models, shear stress forces exceeded 300 Pa. Shear stress increased with blood flow rates and cross-sectional areas of any PVL. There was no linear relationship between cross-sectional area of a PVL and volume of a PVL channel with shear stress > 300 Pa. Blood flow through mitral PVLs is associated with shear stress above 300 Pa. Cross-sectional area of a PVL does not correlate with volume of a PVL channel with shear stress > 300 Pa and duration of exposure of erythrocytes to shear stress > 300 Pa.
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Registered trials
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