Evidence map›Paper›PMID 34945004›Full record

ArticleCancers2021

Artificial Neural Networks Predicted the Overall Survival and Molecular Subtypes of Diffuse Large B-Cell Lymphoma Using a Pancancer Immune-Oncology Panel.

Joaquim Carreras, Shinichiro Hiraiwa, Yara Yukie Kikuti, Masashi Miyaoka, Sakura Tomita, Haruka Ikoma, Atsushi Ito, Yusuke Kondo, Giovanna Roncador, Juan F Garcia and 3 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Artificial intelligence for predicting 30-day mortality after emergency laparotomy.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Deep Learning in Hematology: From Molecules to Patients.Clinical hematology international · 2024
    Review
  13. Artificial intelligence and classification of mature lymphoid neoplasms.Exploration of targeted anti-tumor therapy · 2024
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 4 countries.

Joaquim CarrerasDepartment of Pathology, School of Medicine, Tokai University, 143 Shimokasuya, Isehara 259-1193, Japan.ORCID 0000-0002-6129-8299
Shinichiro HiraiwaDepartment of Pathology, School of Medicine, Tokai University, 143 Shimokasuya, Isehara 259-1193, Japan.
Yara Yukie KikutiDepartment of Pathology, School of Medicine, Tokai University, 143 Shimokasuya, Isehara 259-1193, Japan.
Masashi MiyaokaDepartment of Pathology, School of Medicine, Tokai University, 143 Shimokasuya, Isehara 259-1193, Japan.
Sakura TomitaDepartment of Pathology, School of Medicine, Tokai University, 143 Shimokasuya, Isehara 259-1193, Japan.
Haruka IkomaDepartment of Pathology, School of Medicine, Tokai University, 143 Shimokasuya, Isehara 259-1193, Japan.
Atsushi ItoDepartment of Pathology, School of Medicine, Tokai University, 143 Shimokasuya, Isehara 259-1193, Japan.
Yusuke KondoDepartment of Pathology, School of Medicine, Tokai University, 143 Shimokasuya, Isehara 259-1193, Japan.
Giovanna RoncadorMonoclonal Antibodies Unit, Spanish National Cancer Research Center (Centro Nacional de Investigaciones Oncologicas, CNIO), Melchor Fernandez Almagro 3, 28029 Madrid, Spain.
Juan F GarciaDepartment of Pathology, MD Anderson Cancer Center Madrid, Calle de Arturo Soria 270, 28033 Madrid, Spain.ORCID 0000-0001-6974-0806
Kiyoshi AndoDepartment of Hematology, School of Medicine, Tokai University, 143 Shimokasuya, Isehara 259-1193, Japan.
Rifat HamoudiSharjah Institute for Medical Research, Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates.ORCID 0000-0002-1402-0868
Naoya NakamuraDepartment of Pathology, School of Medicine, Tokai University, 143 Shimokasuya, Isehara 259-1193, Japan.
Tokai University · JPMD Anderson Cancer Center Madrid · ESSpanish National Cancer Research Centre · ESUniversity of Sharjah · AE

Funding

AL-JALILA FOUNDATION AJF2018090Ministry of Education, Culture, Sports, Science and Technology KAKEN 15K19061Ministry of Education, Culture, Sports, Science and Technology KAKEN 18K15100Tokai University TOKAI UNIVERSITY SCHOOL OF MEDICINE, RESEARCH INCENTIVE ASSISTANT PLAN 2021-B04University of Sharjah 1901090258
6 · The paper itself

Abstract

Diffuse large B-cell lymphoma (DLBCL) is one of the most frequent subtypes of non-Hodgkin lymphomas. We used artificial neural networks (multilayer perceptron and radial basis function), machine learning, and conventional bioinformatics to predict the overall survival and molecular subtypes of DLBCL. The series included 106 cases and 730 genes of a pancancer immune-oncology panel (nCounter) as predictors. The multilayer perceptron predicted the outcome with high accuracy, with an area under the curve (AUC) of 0.98, and ranked all the genes according to their importance. In a multivariate analysis,

Indexed as

artificial intelligenceartificial neural networksdiffuse large B-cell lymphomamachine learningmolecular subtypemultilayer perceptronoverall survivalpancancer immune-oncology panelprognosisradial basis function

Identifiers

PMID34945004
PMCPMC8699516
OpenAlexW4200450486

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.