Evidence map›Paper›PMID 34944977›Full record

ArticleCancers2021

Orai1 Boosts SK3 Channel Activation.

Adéla Tiffner, Valentina Hopl, Romana Schober, Matthias Sallinger, Herwig Grabmayr, Carmen Höglinger, Marc Fahrner, Victoria Lunz, Lena Maltan, Irene Frischauf and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Adéla TiffnerJKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, A-4020 Linz, Austria.ORCID 0000-0002-7529-4504
Valentina HoplJKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, A-4020 Linz, Austria.
Romana SchoberJKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, A-4020 Linz, Austria.
Matthias SallingerJKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, A-4020 Linz, Austria.
Herwig GrabmayrJKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, A-4020 Linz, Austria.ORCID 0000-0003-0870-5833
Carmen HöglingerJKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, A-4020 Linz, Austria.
Marc FahrnerJKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, A-4020 Linz, Austria.ORCID 0000-0002-2689-0158
Victoria LunzJKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, A-4020 Linz, Austria.
Lena MaltanJKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, A-4020 Linz, Austria.ORCID 0000-0002-2939-2533
Irene FrischaufJKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, A-4020 Linz, Austria.ORCID 0000-0003-0661-2932
Denis KrivicGottfried Schatz Research Centre, Medical University of Graz, A-8010 Graz, Austria.
Rajesh BhardwajDepartment of Nephrology and Hypertension, University of Bern, Inselspital, Freiburgstrasse 15, CH-3010 Bern, Switzerland.ORCID 0000-0002-5599-487X
Rainer SchindlGottfried Schatz Research Centre, Medical University of Graz, A-8010 Graz, Austria.ORCID 0000-0003-0896-8887
Matthias A HedigerDepartment of Nephrology and Hypertension, University of Bern, Inselspital, Freiburgstrasse 15, CH-3010 Bern, Switzerland.ORCID 0000-0003-1946-027X
Isabella DerlerJKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, A-4020 Linz, Austria.
Johannes Kepler University of Linz · ATMedical University of Graz · ATUniversity of Bern · CH

Funding

Austrian Science Fund FWF P 30567Austrian Science Fund FWF P 32075Austrian Science Fund FWF P 32851Austrian Science Fund FWF P 32947Austrian Science Fund FWF W 1226Austrian Science Fund FWF W 1250
6 · The paper itself

Abstract

The interplay of SK3, a Ca

Indexed as

Ca2+ activated K+ ion channelscalmodulinCRAC channelLNCaP cellsOrai1SK3SK channelsSTIM1

Identifiers

PMID34944977
PMCPMC8699475
OpenAlexW4200214568

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.