Evidence map›Paper›PMID 34944963›Full record

ReviewCancers2021

New Trends in the Detection of Gynecological Precancerous Lesions and Early-Stage Cancers.

Jitka Holcakova, Martin Bartosik, Milan Anton, Lubos Minar, Jitka Hausnerova, Marketa Bednarikova, Vit Weinberger, Roman Hrstka

Abstract readReview
In one paragraph

Review in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  4. Detection ofOncology research · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jitka HolcakovaResearch Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, 656 53 Brno, Czech Republic.
Martin BartosikResearch Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, 656 53 Brno, Czech Republic.ORCID 0000-0002-4728-1626
Milan AntonDepartment of Obstetrics and Gynecology, Masaryk University and University Hospital, 625 00 Brno, Czech Republic.
Lubos MinarDepartment of Obstetrics and Gynecology, Masaryk University and University Hospital, 625 00 Brno, Czech Republic.
Jitka HausnerovaDepartment of Pathology, Masaryk University and University Hospital, 625 00 Brno, Czech Republic.
Marketa BednarikovaDepartment of Internal Medicine, Hematology and Oncology, Masaryk University and University Hospital, 625 00 Brno, Czech Republic.
Vit WeinbergerDepartment of Obstetrics and Gynecology, Masaryk University and University Hospital, 625 00 Brno, Czech Republic.ORCID 0000-0003-4858-1951
Roman HrstkaResearch Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, 656 53 Brno, Czech Republic.ORCID 0000-0002-6139-2664

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prevention and early diagnostics of precancerous stages are key aspects of contemporary oncology. In cervical cancer, well-organized screening and vaccination programs, especially in developed countries, are responsible for the dramatic decline of invasive cancer incidence and mortality. Cytological screening has a long and successful history, and the ongoing implementation of HPV triage with increased sensitivity can further decrease mortality. On the other hand, endometrial and ovarian cancers are characterized by a poor accessibility to specimen collection, which represents a major complication for early diagnostics. Therefore, despite relatively promising data from evaluating the combined effects of genetic variants, population screening does not exist, and the implementation of new biomarkers is, thus, necessary. The introduction of various circulating biomarkers is of potential interest due to the considerable heterogeneity of cancer, as highlighted in this review, which focuses exclusively on the most common tumors of the genital tract, namely, cervical, endometrial, and ovarian cancers. However, it is clearly shown that these malignancies represent different entities that evolve in different ways, and it is therefore necessary to use different methods for their diagnosis and treatment.

Indexed as

cervical cancerendometrial cancerliquid biopsyovarian cancerprecancer

Identifiers

PMID34944963
PMCPMC8699592

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.