Evidence map›Paper›PMID 34944954›Full record

ReviewCancers2021

Impact of a Faulty Germinal Center Reaction on the Pathogenesis of Primary Diffuse Large B Cell Lymphoma of the Central Nervous System.

Manuel Montesinos-Rongen, Anna Brunn, Monica Sanchez-Ruiz, Ralf Küppers, Reiner Siebert, Martina Deckert

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Updates of primary central nervous system lymphoma.Therapeutic advances in hematology · 2024
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Manuel Montesinos-RongenInstitute of Neuropathology, Faculty of Medicine, University Hospital Cologne, 50937 Cologne, Germany.ORCID 0000-0003-4724-5526
Anna BrunnInstitute of Neuropathology, Faculty of Medicine, University Hospital Cologne, 50937 Cologne, Germany.
Monica Sanchez-RuizInstitute of Neuropathology, Faculty of Medicine, University Hospital Cologne, 50937 Cologne, Germany.
Ralf KüppersInstitute of Cell Biology (Cancer Research), Medical School, University of Duisburg-Essen, 45122 Essen, Germany.ORCID 0000-0002-6691-7191
Reiner SiebertInstitute of Human Genetics, Ulm University and Ulm University Medical Center, 89081 Ulm, Germany.
Martina DeckertInstitute of Neuropathology, Faculty of Medicine, University Hospital Cologne, 50937 Cologne, Germany.
University Hospital Cologne · DEUniversität Ulm · DEUniversity of Duisburg-Essen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary lymphoma of the central nervous system (PCNSL, CNS) is a specific diffuse large B cell lymphoma (DLBCL) entity confined to the CNS. Key to its pathogenesis is a failure of B cell differentiation and a lack of appropriate control at differentiation stages before entrance and within the germinal center (GC). Self-/polyreactive B cells rescued from apoptosis by

Indexed as

animal modelB cell receptorCNSdiffuse large B cell lymphomagerminal centermicroenvironmentmolecular pathogenesismousePCNSLsomatic hypermutation

Identifiers

PMID34944954
PMCPMC8699297
OpenAlexW4200438183

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.