Evidence map›Paper›PMID 34944883›Full record

ArticleCancers2021

Comparison of the Transcriptomic Signatures in Pediatric and Adult CML.

Minyoung Youn, Stephanie M Smith, Alex Gia Lee, Hee-Don Chae, Elizabeth Spiteri, Jason Erdmann, Ilana Galperin, Lara Murphy Jones, Michele Donato, Parveen Abidi and 19 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Expression ofFrontiers in oncology · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Management of Chronic Myeloid Leukemia in Children and Young Adults.Current hematologic malignancy reports · 2022
    Review
  17. EAHP 2020 workshop proceedings, pediatric myeloid neoplasms.Virchows Archiv : an international journal of pathology · 2022
    Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 11 institutions in 2 countries.

Minyoung YounDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Stephanie M SmithDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-3369-7516
Alex Gia LeeDepartment of Pediatrics, University of California, San Francisco, CA 94143, USA.
Hee-Don ChaeDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Elizabeth SpiteriDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Jason ErdmannCytogenetics Laboratory, Stanford Health Care, Stanford, CA 94304, USA.
Ilana GalperinCytogenetics Laboratory, Stanford Health Care, Stanford, CA 94304, USA.
Lara Murphy JonesDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Michele DonatoInstitute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA 94305, USA.
Parveen AbidiDivision of Hematology, Department of Medicine, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
Henrique BittencourtHematology-Oncology Division, Charles Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine, Montreal, QC H3T 1C5, Canada.
Norman LacayoDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0003-4573-5118
Gary DahlDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Catherine AftandilianDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Kara L DavisDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Jairo A MatthewsDepartment of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
Steven M KornblauDepartment of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.ORCID 0000-0002-5990-9548
Min HuangDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Nathan SumarsonoDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Michele S RedellDivision of Pediatric Hematology/Oncology, Baylor College of Medicine, Houston, TX 77030, USA.
Cecilia H FuDivision of Hematology/Oncology, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.
I-Ming ChenDepartment of Pathology, University of New Mexico Comprehensive Cancer Center, Albuquerque, NM 87102, USA.
Todd A AlonzoDepartment of Preventive Medicine, University of Southern California, Los Angeles, CA 90032, USA.
Elizabeth EklundFeinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Jason GotlibDivision of Hematology, Department of Medicine, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
Purvesh KhatriInstitute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA 94305, USA.
E Alejandro Sweet-CorderoDepartment of Pediatrics, University of California, San Francisco, CA 94143, USA.
Nobuko HijiyaDepartment of Pediatrics, Columbia University Irving Medical Center, New York, NY 10032, USA.
Kathleen M SakamotoDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Stanford University · USStanford Health Care · USThe University of Texas MD Anderson Cancer Center · USUniversity of California, San Francisco · USBaylor College of Medicine · USCentre Hospitalier Universitaire Sainte-Justine · CAChildren's Hospital of Los Angeles · USColumbia University Irving Medical Center · USNorthwestern University · USUniversity of New Mexico · USUniversity of Southern California · US

Funding

High Throughput DNA Sequencer UpgradeS10OD018220 · OD · STANFORD UNIVERSITY · PI COLLER, JOHN · 2014 to 2014
$596k
CSRD VA I01 CX001864NIH HHS S10 OD018220
6 · The paper itself

Abstract

Children with chronic myeloid leukemia (CML) tend to present with higher white blood counts and larger spleens than adults with CML, suggesting that the biology of pediatric and adult CML may differ. To investigate whether pediatric and adult CML have unique molecular characteristics, we studied the transcriptomic signature of pediatric and adult CML CD34+ cells and healthy pediatric and adult CD34+ control cells. Using high-throughput RNA sequencing, we found 567 genes (207 up- and 360 downregulated) differentially expressed in pediatric CML CD34+ cells compared to pediatric healthy CD34+ cells. Directly comparing pediatric and adult CML CD34+ cells, 398 genes (258 up- and 140 downregulated), including many in the Rho pathway, were differentially expressed in pediatric CML CD34+ cells. Using RT-qPCR to verify differentially expressed genes, VAV2 and ARHGAP27 were significantly upregulated in adult CML CD34+ cells compared to pediatric CML CD34+ cells. NCF1, CYBB, and S100A8 were upregulated in adult CML CD34+ cells but not in pediatric CML CD34+ cells, compared to healthy controls. In contrast, DLC1 was significantly upregulated in pediatric CML CD34+ cells but not in adult CML CD34+ cells, compared to healthy controls. These results demonstrate unique molecular characteristics of pediatric CML, such as dysregulation of the Rho pathway, which may contribute to clinical differences between pediatric and adult patients.

Indexed as

CML CD34+ cellspediatric CMLRho pathwayRNA sequencingtranscriptome

Identifiers

PMID34944883
PMCPMC8699058
OpenAlexW4226156891

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.