Evidence map›Paper›PMID 34944879›Full record

ArticleCancers2021

Identification of Potential Prognostic and Predictive Immunological Biomarkers in Patients with Stage I and Stage III Non-Small Cell Lung Cancer (NSCLC): A Prospective Exploratory Study.

Rianne D W Vaes, Kobe Reynders, Jenny Sprooten, Kathleen T Nevola, Kasper M A Rouschop, Marc Vooijs, Abhishek D Garg, Maarten Lambrecht, Lizza E L Hendriks, Marijana Rucevic and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
3.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 45 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Rianne D W VaesDepartment of Radiation Oncology (MAASTRO), GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, 6200 MD Maastricht, The Netherlands.ORCID 0000-0001-6812-2897
Kobe ReyndersDepartment of Radiation Oncology (MAASTRO), GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, 6200 MD Maastricht, The Netherlands.
Jenny SprootenCell Stress & Immunity (CSI) Lab, Department for Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0003-3264-5156
Kathleen T NevolaOLINK Proteomics Inc., Waltham, MA 02453, USA.
Kasper M A RouschopDepartment of Radiotherapy, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, 6200 MD Maastricht, The Netherlands.
Marc VooijsDepartment of Radiation Oncology (MAASTRO), GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, 6200 MD Maastricht, The Netherlands.
Abhishek D GargCell Stress & Immunity (CSI) Lab, Department for Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0002-9976-9922
Maarten LambrechtDepartment of Radiotherapy-Oncology, Leuven Kanker Instituut, Universitair Ziekenhuis (UZ) Gasthuisberg, 3000 Leuven, Belgium.
Lizza E L HendriksDepartment of Pulmonary Diseases, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, 6200 MD Maastricht, The Netherlands.ORCID 0000-0002-3521-2535
Marijana RucevicOLINK Proteomics Inc., Waltham, MA 02453, USA.
Dirk De RuysscherDepartment of Radiation Oncology (MAASTRO), GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, 6200 MD Maastricht, The Netherlands.
University Medical Center · USKU Leuven · BEUniversitair Ziekenhuis Leuven · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radiotherapy (RT) and chemotherapy can induce immune responses, but not much is known regarding treatment-induced immune changes in patients. This exploratory study aimed to identify potential prognostic and predictive immune-related proteins associated with progression-free survival (PFS) in patients with non-small cell lung cancer (NSCLC). In this prospective study, patients with stage I NSCLC treated with stereotactic body radiation therapy (

Indexed as

biomarkerschemoradiationimmunogenic cell deathnon-small cell lung cancerpredictiveprognosticstereotactic body radiotherapy

Identifiers

PMID34944879
PMCPMC8699057
OpenAlexW4200380682

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.