Evidence map›Paper›PMID 34944872›Full record

ArticleCancers2021

YAP1 Is a Potential Predictive Molecular Biomarker for Response to SMO Inhibitor in Medulloblastoma Cells.

Gustavo Alencastro Veiga Cruzeiro, Taciani de Almeida Magalhães, Graziella Ribeiro de Sousa, Ricardo Bonfim Silva, Carlos Alberto Oliveira de Biagi Junior, Pablo Ferreira das Chagas, Rosane Gomes de Paula Queiroz, Carlos Alberto Scrideli, Luiz Gonzaga Tone, Elvis Terci Valera

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Knowledge base and emerging trends in YAP1 research.American journal of translational research · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Gustavo Alencastro Veiga CruzeiroDepartment of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, Hospital das Clínicas Ribeirão Preto, Av. Bandeirantes 3900, Ribeirão Preto 05468901, São Paulo, Brazil.
Taciani de Almeida MagalhãesDepartment of Genetics, Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto 05468901, São Paulo, Brazil.
Graziella Ribeiro de SousaDepartment of Genetics, Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto 05468901, São Paulo, Brazil.
Ricardo Bonfim SilvaDepartment of Genetics, Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto 05468901, São Paulo, Brazil.
Carlos Alberto Oliveira de Biagi JuniorDepartment of Genetics, Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto 05468901, São Paulo, Brazil.ORCID 0000-0003-0700-3135
Pablo Ferreira das ChagasDepartment of Genetics, Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto 05468901, São Paulo, Brazil.ORCID 0000-0002-0652-728X
Rosane Gomes de Paula QueirozDepartment of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, Hospital das Clínicas Ribeirão Preto, Av. Bandeirantes 3900, Ribeirão Preto 05468901, São Paulo, Brazil.
Carlos Alberto ScrideliDepartment of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, Hospital das Clínicas Ribeirão Preto, Av. Bandeirantes 3900, Ribeirão Preto 05468901, São Paulo, Brazil.ORCID 0000-0001-6618-789X
Luiz Gonzaga ToneDepartment of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, Hospital das Clínicas Ribeirão Preto, Av. Bandeirantes 3900, Ribeirão Preto 05468901, São Paulo, Brazil.ORCID 0000-0001-8821-4211
Elvis Terci ValeraDepartment of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, Hospital das Clínicas Ribeirão Preto, Av. Bandeirantes 3900, Ribeirão Preto 05468901, São Paulo, Brazil.ORCID 0000-0002-4434-429X
Universidade de São Paulo · BRBroad Institute · USHarvard University · US

Funding

São Paulo Research Foundation 2017/06511-8, 2018/20635-4 and 2014/20341-0
6 · The paper itself

Abstract

Advances in genomics have led to the identification of twelve relevant molecular subtypes within medulloblastoma (MB). The alpha subtype of Sonic hedgehog-driven MB is resistant to therapy (including smoothened inhibitors) due to activation of genes from the non-canonical SHH pathway, such as

Indexed as

SHH medulloblastomaSMO inhibitorYAP1

Identifiers

PMID34944872
PMCPMC8699675
OpenAlexW4200600333

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.