ArticleCancers2021
Higher Radiation Dose to the Immune Cells Correlates with Worse Tumor Control and Overall Survival in Patients with Stage III NSCLC: A Secondary Analysis of RTOG0617.
Open access · goldAbstract read
In one paragraph
Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 1 pooled it
10.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
88 citing papers in PubMed, 1 synthesis or guideline pooled it, 115 citations in OpenAlex.
- Synergies between radiotherapy and immunotherapy: a systematic review from mechanism to clinical application.Frontiers in immunology · 2025Pooled it
- Primary Results of NRG-RTOG1106/ECOG-ACRIN 6697: A Randomized Phase II Trial of Individualized Adaptive (chemo)Radiotherapy Using MidtreatmentJournal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024Trial
- The impact of effective dose to the immune cells on survival in breast cancer patients.Clinical and translational radiation oncology · 2026Article
- Innovative Strategies in the Treatment of Unresectable Locally Advanced NSCLC: A Focus on Radiation Therapy.Cancers · 2026Review
- Definitive radiotherapy for non-small-cell lung cancer: current practice and future directions.Japanese journal of radiology · 2026Review
- Immune-sparing radiotherapy in solid tumors: radiation-induced lymphopenia, circulating immune-cell dose, and biomarker-guided optimization of radioimmunotherapy.Journal of cancer research and clinical oncology · 2026Review
- Immune-preserving radiotherapy and perioperative immunotherapy in stage III NSCLC: a narrative review of current management and future directions for IIIA/IIIB NSCLC.Translational lung cancer research · 2026Review
- The estimated dose of radiation to immune cells predicts lymphopenia and reveals technique-Dependent immune sparing in postoperative radiotherapy for early esophageal cancer.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026Article
- Article
- Radiation induced lymphopenia during PRRT: Incidence, course, predictive factors, and association with overall survival.European journal of nuclear medicine and molecular imaging · 2026Article
- Predicting Post-Radiotherapy Lymphocyte Recovery for Individualized Risk Stratification in Locally Advanced Esophageal Squamous Cell Carcinoma.Current oncology (Toronto, Ont.) · 2026Article
- The Prognostic Value of EDRIC and Its Association With Radiation-Induced Lymphopenia in Patients With Esophageal Cancer Undergoing Radical Radiotherapy: A Single-Center Chinese Study.The Kaohsiung journal of medical sciences · 2026Article
- Article
- Assessment of proton versus photon therapy in the reduction of lymphopaenia in thoracic cancers: A scoping review.Technical innovations & patient support in radiation oncology · 2026Review
- Histopathological characteristics of screen-detected colorectal cancers.Virchows Archiv : an international journal of pathology · 2026Article
- Impact of effective dose to immune cells (EDIC) on survival in limited-stage small cell lung cancer treated with radiotherapy and immunotherapy.Translational lung cancer research · 2026Article
- Article
- Clinical impact of novel cardiovascular and immune system dosimetric parameters in stage III NSCLC patients treated with radiotherapy.Radiation oncology (London, England) · 2026Article
- The role of KPNA3 in multiple myeloma: implications for targeting nuclear import.Apoptosis : an international journal on programmed cell death · 2026Article
- Local FLASH radiation exhibits a double-edged effect on the mouse immune system.Radiation oncology (London, England) · 2026Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 17 institutions in 3 countries.
Jian-Yue JinDepartment of Radiation Oncology, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH 44106, USA.
Chen HuNRG Oncology Statistics and Data Management Center, Philadelphia, PA 19103, USA.
Ying XiaoAbramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19103, USA.
Hong ZhangDepartment of Radiation Oncology, School of Medicine, University of Maryland, Maryland, MD 20742, USA.
Rebecca PaulusNRG Oncology Statistics and Data Management Center, Philadelphia, PA 19103, USA.
Susannah G EllsworthDepartment of Radiation Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA 16251, USA.
Steven E SchildDepartment of Radiation Oncology, Mayo Clinic Hospital, Phoenix, AZ 85054, USA.
Jeffrey A BogartDepartment of Radiation Oncology, State University of New York Upstate Medical University, Syracuse, NY 13210, USA.
Michael Chris DobelbowerDepartment of Radiation Oncology, University of Alabama at Birmingham Cancer Center, Birmingham, AL 35233, USA.
Vivek S KavadiUSON-Texas Oncology-Sugar Land, Sugar Land, TX 77479, USA.
Samir NarayanMichigan Cancer Research Consortium CCOP, Ann Arbor, MI 48106, USA.
Puneeth IyengarDepartment of Radiation Oncology, University of Texas Southwestern Medical School, Dallas, TX 75235, USA.
Cliff RobinsonDepartment of Radiation Oncology, Washington University in St. Louis, St. Louis, MO 63108, USA.
Joel S GreenbergerDepartment of Radiation Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA 16251, USA.
Christopher KoprowskiChristiana Care Health Services, Inc. CCOP, Newark, DE 19718, USA.
Mitchell MachtayDepartment of Radiation Oncology, Penn State University Cancer Institute, Hershey, PA 17033, USA.
Walter CurranDepartment of Radiation Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA.
Hak ChoyDepartment of Radiation Oncology, University of Texas Southwestern Medical School, Dallas, TX 75235, USA.
Jeffrey D BradleyDepartment of Radiation Oncology, Washington University in St. Louis, St. Louis, MO 63108, USA.
Feng-Ming Spring KongDepartment of Clinical Oncology, Hong Kong University Shenzhen Hospital, Shenzhen 518009, China.ORCID 0000-0003-2652-098X
The University of Texas Southwestern Medical Center · USUniversity of Pittsburgh Medical Center · USWashington University in St. Louis · USChristiana Care Health System · USEmory University · USJohns Hopkins University · USMayo Clinic Hospital · USMichigan Cancer Research Consortium · USNRG Oncology · USPennsylvania State University · USQueen Mary Hospital · CNSUNY Upstate Medical University · USTexas Oncology · USUniversity Hospitals of Cleveland · USUniversity of Alabama at Birmingham · USUniversity of Maryland, Baltimore · USUniversity of Pennsylvania · US
Funding
NRG Oncology Network Group Operations Center - GY9 BIQSFP Reports/BudgetsU10CA180868 · NCI · NRG ONCOLOGY FOUNDATION, INC. · PI NORMAN WOLMARK · 2014 to 2026
$206.8MStatistics CoreU10CA180822 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI James J. Dignam · 2014 to 2026
$146.4MNRG Oncology NCORP Research Base-BIQSFPUG1CA189867 · NCI · NRG ONCOLOGY FOUNDATION, INC. · PI Deborah Watkins Bruner, Lisa A. Kachnic · 2014 to 2026
$140.5MIROC: Enhancing local enrolling site radiological data capture capabilities for NCTN trialsU24CA180803 · NCI · AMERICAN COLLEGE OF RADIOLOGY · PI Thomas J. FitzGerald, MICHAEL V KNOPP · 2014 to 2026
$116.2MUT Southwestern NCI National Clinical Trials Network (NCTN) LAPS - Supplemental Funds YR4UG1CA233302 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI David Eric Gerber · 2019 to 2026
$6.4MFUNCTIONAL IMAGE AND MOLECULAR MARKER TO INDIVIDUALIZE ADAPTIVE RADIATION DOSE ESR01CA142840 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KONG, FENG-MING P. · 2010 to 2015
$2.0MNCI NIH HHS U10 CA180822NCI NIH HHS U10 CA180868NCI NIH HHS U24 CA180803NCI NIH HHS UG1 CA189867NCI NIH HHS UG1 CA233302NIH HHS R01CA142840NIH HHS U10CA180822NIH HHS U10CA180868NIH HHS UG1CA189867
Abstract
PubMed holds no abstract for this paper.
Indexed as
non-small-cell lung cancerradiation-induced immune toxicityradiotherapysurvival
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.