Evidence map›Paper›PMID 34944800›Full record

ArticleCancers2021

Efficacy and Synergy of Small Molecule Inhibitors Targeting

Javier Bregante, Anna Schönbichler, Daniel Pölöske, Lina Degenfeld-Schonburg, Garazi Monzó Contreras, Emir Hadzijusufovic, Elvin D de Araujo, Peter Valent, Richard Moriggl, Anna Orlova

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Javier BreganteInstitute of Animal Breeding and Genetics, University of Veterinary Medicine, 1210 Vienna, Austria.ORCID 0000-0002-5587-0500
Anna SchönbichlerInstitute of Animal Breeding and Genetics, University of Veterinary Medicine, 1210 Vienna, Austria.
Daniel PölöskeInstitute of Animal Breeding and Genetics, University of Veterinary Medicine, 1210 Vienna, Austria.
Lina Degenfeld-SchonburgDepartment of Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, 1090 Vienna, Austria.
Garazi Monzó ContrerasInstitute of Animal Breeding and Genetics, University of Veterinary Medicine, 1210 Vienna, Austria.
Emir HadzijusufovicDepartment of Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0001-7409-4204
Elvin D de AraujoDepartment of Chemical and Physical Sciences, University of Toronto Mississauga, Mississauga, ON L5L1C6, Canada.
Peter ValentDepartment of Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0003-0456-5095
Richard MorigglInstitute of Animal Breeding and Genetics, University of Veterinary Medicine, 1210 Vienna, Austria.ORCID 0000-0003-0918-9463
Anna OrlovaInstitute of Animal Breeding and Genetics, University of Veterinary Medicine, 1210 Vienna, Austria.ORCID 0000-0001-9262-7529
University of Veterinary Medicine Vienna · ATMedical University of Vienna · ATUniversity of Toronto · CA

Funding

Austrian Science Fund FWF I 4157
6 · The paper itself

Abstract

Constitutive activation of FLT3 by ITD mutations is one of the most common genetic aberrations in AML, present in ~1/3 of cases. Patients harboring

Indexed as

acute myeloid leukemiacabozantinibFMS-like tyrosine kinase 3ispinesibponatinibtargeted therapytyrosine kinase inhibitorWS6

Identifiers

PMID34944800
PMCPMC8699584
OpenAlexW4200341457

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.