Evidence map›Paper›PMID 34944790›Full record

ArticleCancers2021

Transcriptional Regulation of Amino Acid Transport in Glioblastoma Multiforme.

Robyn A Umans, Joelle Martin, Megan E Harrigan, Dipan C Patel, Lata Chaunsali, Aarash Roshandel, Kavya Iyer, Michael D Powell, Ken Oestreich, Harald Sontheimer

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Review
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  7. Review
  8. Stroma AReactive Invasion Front Areas (SARIFA) proves prognostic relevance in gastric carcinoma and is based on a tumor-adipocyte interaction indicating an altered immune response.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2024
    Article
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  13. Ferroptosis Involvement in Glioblastoma Treatment.Medicina (Kaunas, Lithuania) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Robyn A UmansCenter for Glial Biology in Health, Disease and Cancer, The Fralin Biomedical Research Institute at VTC, Roanoke, VA 24016, USA.
Joelle MartinCenter for Glial Biology in Health, Disease and Cancer, The Fralin Biomedical Research Institute at VTC, Roanoke, VA 24016, USA.
Megan E HarriganCenter for Glial Biology in Health, Disease and Cancer, The Fralin Biomedical Research Institute at VTC, Roanoke, VA 24016, USA.
Dipan C PatelDepartment of Neuroscience, University of Virginia School of Medicine, Charlottesville, VA 22903, USA.ORCID 0000-0002-1381-5351
Lata ChaunsaliDepartment of Neuroscience, University of Virginia School of Medicine, Charlottesville, VA 22903, USA.ORCID 0000-0003-1533-7151
Aarash RoshandelCollege of Agriculture and Life Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
Kavya IyerRoanoke College, Salem, VA 24153, USA.
Michael D PowellDepartment of Microbiology and Immunity, Emory University School of Medicine, Atlanta, GA 30322, USA.
Ken OestreichMicrobial Infection and Immunity, The Ohio State University College of Medicine, Columbus, OH 43210, USA.
Harald SontheimerDepartment of Neuroscience, University of Virginia School of Medicine, Charlottesville, VA 22903, USA.ORCID 0000-0002-5843-9871
Biomedical Research Institute · USUniversity of Virginia · USEmory University · USRoanoke College · USThe Ohio State University · USVirginia Tech · US

Funding

The Role of Ion Transport in Glioma Migration, Proliferation, and ApoptosisR01NS036692 · NINDS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI SONTHEIMER, HARALD W · 1997 to 2024
$6.8M
Identifying novel regulatory pathways underlying T helper 1 cell immune responsesR01AI134972 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI OESTREICH, KENNETH JOSEPH · 2018 to 2022
$1.9M
Regulation of Amino-acid Transport in Human GliomasR01CA227149 · NCI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI SONTHEIMER, HARALD W · 2019 to 2023
$1.8M
NCI NIH HHS 1R01CA227149-01A1NCI NIH HHS R01 CA227149NIAID NIH HHS R01 AI134972NIH HHS 1R01CA227149-01A1NINDS NIH HHS R01 NS036692
6 · The paper itself

Abstract

Glioblastoma multiforme (GBM) is a deadly brain tumor with a large unmet therapeutic need. Here, we tested the hypothesis that wild-type p53 is a negative transcriptional regulator of

Indexed as

glioblastoma multiformeglutamatep53SLC7A11

Identifiers

PMID34944790
PMCPMC8699180
OpenAlexW4200377054

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.