Evidence map›Paper›PMID 34944787›Full record

ArticleCancers2021

Integrative Analysis Identifies Multi-Omics Signatures That Drive Molecular Classification of Uveal Melanoma.

Qianxing Mo, Lixin Wan, Michael J Schell, Heather Jim, Shelley S Tworoger, Guang Peng

Abstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Statistical Methods for Integrative Clustering of Multi-omics Data.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qianxing MoDepartment of Biostatistics & Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.ORCID 0000-0002-0021-7694
Lixin WanDepartment of Molecular Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Michael J SchellDepartment of Biostatistics & Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Heather JimDepartment of Health Outcomes & Behavior, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.ORCID 0000-0001-7353-3711
Shelley S TworogerDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Guang PengDepartment of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI Christine O'Connell · 1998 to 2026
$93.5M
Novel Biomarkers for Cancer-Related Fatigue: Integrating Metabolomics, Genomics and BehaviorsR01NR018762 · NINR · CEDARS-SINAI MEDICAL CENTER · PI FIGUEIREDO, JANE C., JIM, HEATHER S.L. · 2020 to 2024
$3.4M
Mechanisms of radioresistance and strategies for radiosensitization in ovarian clear cell carcinomaR01CA181663 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Guang Peng · 2016 to 2026
$3.1M
NCI NIH HHS P30 CA076292NCI NIH HHS R01 CA181663NINR NIH HHS R01 NR018762
6 · The paper itself

Abstract

By iCluster analysis, we found that the integrative molecular classification of the UM was primarily driven by DNA copy number variation on chromosomes 3, 6 and 8, differential methylation and expression of genes involved in the immune system, cell morphogenesis, movement and migration, and differential mutation of genes including

Indexed as

hypermethylationhypomethylationiClusterintegrative clusteringintegrative subtypeiSubtypemetastasismolecular classificationuveal melanoma

Identifiers

PMID34944787
PMCPMC8699355

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.