Evidence map›Paper›PMID 34944716›Full record

ArticleBiomedicines2021

Transcriptional Active Parvovirus B19 Infection Predicts Adverse Long-Term Outcome in Patients with Non-Ischemic Cardiomyopathy.

Felicitas Escher, Ganna Aleshcheva, Heiko Pietsch, Christian Baumeier, Ulrich M Gross, Benedikt Norbert Schrage, Dirk Westermann, Claus-Thomas Bock, Heinz-Peter Schultheiss

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Felicitas EscherInstitute of Cardiac Diagnostics and Therapy, IKDT GmbH, 12203 Berlin, Germany.ORCID 0000-0003-0678-5681
Ganna AleshchevaInstitute of Cardiac Diagnostics and Therapy, IKDT GmbH, 12203 Berlin, Germany.
Heiko PietschInstitute of Cardiac Diagnostics and Therapy, IKDT GmbH, 12203 Berlin, Germany.
Christian BaumeierInstitute of Cardiac Diagnostics and Therapy, IKDT GmbH, 12203 Berlin, Germany.
Ulrich M GrossInstitute of Cardiac Diagnostics and Therapy, IKDT GmbH, 12203 Berlin, Germany.
Benedikt Norbert SchrageDepartment of Cardiology, University Heart and Vascular Center Hamburg, 20246 Hamburg, Germany.
Dirk WestermannDepartment of Cardiology, University Heart and Vascular Center Hamburg, 20246 Hamburg, Germany.
Claus-Thomas BockDepartment of Infectious Diseases, Division of Viral Gastroenteritis and Hepatitis Pathogens and Enteroviruses, Robert Koch Institute, 13353 Berlin, Germany.ORCID 0000-0002-2773-486X
Heinz-Peter SchultheissInstitute of Cardiac Diagnostics and Therapy, IKDT GmbH, 12203 Berlin, Germany.
CS Diagnostics · DEGerman Centre for Cardiovascular Research · DEHumboldt-Universität zu Berlin · DERobert Koch Institute · DE

Funding

Deutsche Forschungsgemeinschaft NCT02970227ERA-Net on Cardiovascular Diseases JTC2016-40-158Investitionsbank Berlin/cofounded of EFRE No. 10169096, 10169098, 10169028
6 · The paper itself

Abstract

Parvovirus B19 (B19V) is the predominant cardiotropic virus currently found in endomyocardial biopsies (EMBs). However, direct evidence showing a causal relationship between B19V and progression of inflammatory cardiomyopathy are still missing. The aim of this study was to analyze the impact of transcriptionally active cardiotropic B19V infection determined by viral RNA expression upon long-term outcomes in a large cohort of adult patients with non-ischemic cardiomyopathy in a retrospective analysis from a prospective observational cohort. In total, the analyzed study group comprised 871 consecutive B19V-positive patients (mean age 50.0 ± 15.0 years) with non-ischemic cardiomyopathy who underwent EMB. B19V-positivity was ascertained by routine diagnosis of viral genomes in EMBs. Molecular analysis of EMB revealed positive B19V transcriptional activity in

Indexed as

dilated inflammatory cardiomyopathylong-term outcomeparvovirus B19transcriptional activity

Identifiers

PMID34944716
PMCPMC8698988
OpenAlexW4200601224

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.