Evidence map›Paper›PMID 34944634›Full record

ArticleBiomedicines2021

Characteristics and Outcomes in Primary Aldosteronism Patients Harboring Glucocorticoid-Remediable Aldosteronism.

Chung-Yi Cheng, Hung-Wei Liao, Kang-Yung Peng, Tso-Hsiao Chen, Yen-Hung Lin, Jeff S Chueh, Vin-Cent Wu, On Behalf Of The Taipai Study Group

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Fat mass as an important predictor of persistent hypertension in patients with primary aldosteronism after adrenalectomy.Hypertension research : official journal of the Japanese Society of Hypertension · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Chung-Yi ChengDivision of Nephrology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, No. 250 Wu-Hsing Street, Taipei 110, Taiwan.
Hung-Wei LiaoChinru Clinic, Taipei 116, Taiwan.ORCID 0000-0003-3090-1937
Kang-Yung PengDepartment of Internal Medicine, National Taiwan University Hospital, Room 1555, Clinical Research Building, 7 Chung-Suan South Road, Taipei 100, Taiwan.ORCID 0000-0002-5773-676X
Tso-Hsiao ChenDivision of Nephrology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, No. 250 Wu-Hsing Street, Taipei 110, Taiwan.
Yen-Hung LinDepartment of Internal Medicine, National Taiwan University Hospital, Room 1555, Clinical Research Building, 7 Chung-Suan South Road, Taipei 100, Taiwan.
Jeff S ChuehDepartment of Urology, College of Medicine, National Taiwan University, National Taiwan University Hospital, Taipei 110, Taiwan.
Vin-Cent WuDepartment of Internal Medicine, National Taiwan University Hospital, Room 1555, Clinical Research Building, 7 Chung-Suan South Road, Taipei 100, Taiwan.ORCID 0000-0001-7935-0991
On Behalf Of The Taipai Study Group
National Taiwan University Hospital · TWWan Fang Hospital · TW

Funding

Grant MOHW 110-TDU-B-212-124005Ministry of Science and Technology, Taiwan MOST107-2314-B-002-026-MY3, 108-2314-B-002-058, 109-2314-B-002-174-MY3National Health Research Institutes, Taiwan PH-102-SP-09National Taiwan University Hospital 109-S4634, PC-1264, PC-1309, VN109-09, UN109-041, UN110-030
6 · The paper itself

Abstract

The clinical characteristics and surgical prognosis of glucocorticoid-remediable aldosteronism (GRA, also known as familial hyperaldosteronism type 1, FH-I) have not been widely studied. Using data from the Taiwan Primary Aldosteronism Investigation (TAIPAI) registry retrospectively, we describe the associated clinical factors for GRA and clinical predictors of surgical outcomes among identified GRA patients. We found 79 GRA-positive (51.2 ± 13.8 years; women 39 (49.4%)) and 114 GRA-negative primary aldosteronism (PA) patients matched with age, gender, and body mass index. Lower plasma aldosterone concentrations (PACs) and aldosterone-renin ratios were found among GRA-positive individuals. Multivariable logistic regression demonstrated that a PAC ≤ 40 ng/dL could predict concealed GRA individuals (OR 0.523,

Indexed as

adrenalectomyglucocorticoid-remediable aldosteronismhypokalemiaplasma renin activity

Identifiers

PMID34944634
PMCPMC8698750
OpenAlexW4200451647

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.