Evidence map›Paper›PMID 34944492›Full record

ArticleBiomolecules2021

Probing the Influence of Single-Site Mutations in the Central Cross-β Region of Amyloid β (1-40) Peptides.

Jacob Fritzsch, Alexander Korn, Dayana Surendran, Martin Krueger, Holger A Scheidt, Kaustubh R Mote, Perunthiruthy K Madhu, Sudipta Maiti, Daniel Huster

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Amyloidogenesis: What Do We Know So Far?International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Jacob FritzschInstitute for Medical Physics and Biophysics, Leipzig University, Härtelstr. 16-18, D-04107 Leipzig, Germany.
Alexander KornInstitute for Medical Physics and Biophysics, Leipzig University, Härtelstr. 16-18, D-04107 Leipzig, Germany.
Dayana SurendranDepartment of Chemical Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Colaba, Mumbai 400005, India.ORCID 0000-0002-2163-1691
Martin KruegerInstitute of Anatomy, Leipzig University, Liebigstr. 13, D-04103 Leipzig, Germany.
Holger A ScheidtInstitute for Medical Physics and Biophysics, Leipzig University, Härtelstr. 16-18, D-04107 Leipzig, Germany.ORCID 0000-0001-9935-8229
Kaustubh R MoteTata Institute of Fundamental Research Hyderabad, 36/P Gopanpally Village, Serilingampally Mandal, Hyderabad 500046, India.
Perunthiruthy K MadhuTata Institute of Fundamental Research Hyderabad, 36/P Gopanpally Village, Serilingampally Mandal, Hyderabad 500046, India.ORCID 0000-0003-2397-4388
Sudipta MaitiDepartment of Chemical Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Colaba, Mumbai 400005, India.
Daniel HusterInstitute for Medical Physics and Biophysics, Leipzig University, Härtelstr. 16-18, D-04107 Leipzig, Germany.ORCID 0000-0002-3273-0943
Leipzig University · DETata Institute of Fundamental Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amyloid β (Aβ) is a peptide known to form amyloid fibrils in the brain of patients suffering from Alzheimer's disease. A complete mechanistic understanding how Aβ peptides form neurotoxic assemblies and how they kill neurons has not yet been achieved. Previous analysis of various Aβ

Indexed as

MutationAmyloid beta-PeptidesCell LineCircular DichroismHumansHydrophobic and Hydrophilic InteractionsLeucineModels, MolecularPhenylalanineProtein Structure, SecondaryX-Ray DiffractionAmyloid beta-PeptidesLeucinePhenylalanineamyloid structure formationfibril dynamicssolid-state NMR

Identifiers

PMID34944492
PMCPMC8699037
OpenAlexW4200613961

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.