Evidence map›Paper›PMID 34944438›Full record

ArticleBiomolecules2021

Exploring the Value of

Nafisa Barma, Timothy C Stone, Lina Maria Carmona Echeverria, Susan Heavey

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Nafisa BarmaDivision of Surgery and Interventional Sciences, University College London, London WC1E 6BT, UK.
Timothy C StoneDivision of Surgery and Interventional Sciences, University College London, London WC1E 6BT, UK.
Lina Maria Carmona EcheverriaDivision of Surgery and Interventional Sciences, University College London, London WC1E 6BT, UK.ORCID 0000-0001-6546-8980
Susan HeaveyDivision of Surgery and Interventional Sciences, University College London, London WC1E 6BT, UK.ORCID 0000-0002-2974-4578
University College London · GBUniversity College London Hospitals NHS Foundation Trust · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsDespite recent advances in advanced prostate cancer treatments, clinical biomarkers or treatments for men with such cancers are imperfect. Targeted therapies have shown promise, but there remain fewer actionable targets in prostate cancer than in other cancers. This work aims to characterise MATERIALS AND

methodsOmics data from a total of 2053 prostate cancer patients across 11 independent datasets were accessed via Cancertool and cBioPortal. mRNA M.expression and co-expression, mutations, amplifications, and deletions were assessed with respect to key clinical parameters including survival, Gleason grade, stage, progression, and treatment. Network and pathway analysis was carried out using Genemania, and heatmaps were constructed using Morpheus.

resultsSUMMARY AND

conclusions

Indexed as

Up-RegulationAndrogen AntagonistsAntineoplastic AgentsBiomarkers, TumorBromodomain Containing ProteinsComputational BiologyDatabases, GeneticDisease ProgressionGene Expression Regulation, NeoplasticHumansMaleMolecular Targeted TherapyNeoplasm GradingProstatic NeoplasmsSignal TransductionTranscription FactorsAndrogen AntagonistsAntineoplastic AgentsBiomarkers, TumorBRD9 protein, humanBromodomain Containing ProteinsTranscription FactorsBRD9prostate cancerSWI/SNFtargeted therapy

Identifiers

PMID34944438
PMCPMC8698755
OpenAlexW3217086637

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.