Evidence map›Paper›PMID 34944431›Full record

ArticleBiomolecules2021

Hydrogen Bond Arrangement Is Shown to Differ in Coexisting Phases of Aqueous Two-Phase Systems.

Pedro P Madeira, Amber R Titus, Luisa A Ferreira, Alexander I Belgovskiy, Elizabeth K Mann, Jay Adin Mann, William V Meyer, Anthony E Smart, Vladimir N Uversky, Boris Y Zaslavsky

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Biomolecular condensates-Prerequisites for anhydrobiosis?Protein science : a publication of the Protein Society · 2025
    Review
  2. Article
  3. Mechanism of Phase Separation in Aqueous Two-Phase Systems.International journal of molecular sciences · 2022
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Pedro P MadeiraDepartment of Chemistry, Centro de Investigacao em Materiais Ceramicos e Compositos, 3810-193 Aveiro, Portugal.
Amber R TitusCleveland Diagnostics, 3615 Superior Ave., Cleveland, OH 44114, USA.ORCID 0000-0002-9670-2634
Luisa A FerreiraCleveland Diagnostics, 3615 Superior Ave., Cleveland, OH 44114, USA.
Alexander I BelgovskiyCleveland Diagnostics, 3615 Superior Ave., Cleveland, OH 44114, USA.
Elizabeth K MannDepartment of Physics, Kent State University, Kent, OH 44242, USA.
Jay Adin MannDepartment of Chemical and Biomolecular Engineering, Case Western Reserve University, Cleveland, OH 44242, USA.
William V MeyerScattering Solutions, Inc., Cleveland, OH 44242, USA.ORCID 0000-0002-2474-7630
Anthony E SmartScattering Solutions, Inc., Costa Mesa, CA 02138, USA.ORCID 0000-0003-2721-5995
Vladimir N UverskyDepartment of Molecular Medicine, Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33620, USA.ORCID 0000-0002-4037-5857
Boris Y ZaslavskyCleveland Diagnostics, 3615 Superior Ave., Cleveland, OH 44114, USA.
Cleveland Research (United States) · USCase Western Reserve University · USKent State University · USUniversity of South Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Analysis by attenuated total reflection-Fourier transform infrared spectroscopy shows that each coexisting phase in aqueous two-phase systems has a different arrangement of hydrogen bonds. Specific arrangements vary for systems formed by different solutes. The hydrogen bond arrangement is shown to correlate with differences in hydrophobic and electrostatic properties of the different phases of five specific systems, four formed by two polymers and one by a single polymer and salt. The results presented here suggest that the arrangement of hydrogen bonds may be an important factor in phase separation.

Indexed as

Hydrogen BondingHydrophobic and Hydrophilic InteractionsLiquid-Liquid ExtractionSaltsSolventsSpectroscopy, Fourier Transform InfraredStatic ElectricityWaterSaltsSolventsWateraqueous two-phase systemattenuated total reflection–Fourier transform infrared spectroscopyliquid–liquid phase separationsolvent propertieswater structure

Identifiers

PMID34944431
PMCPMC8698934
OpenAlexW3217025602

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.