Evidence map›Paper›PMID 34944429›Full record

ArticleBiomolecules2021

Identification, Synthesis, Conformation and Activity of an Insulin-like Peptide from a Sea Anemone.

Michela L Mitchell, Mohammed Akhter Hossain, Feng Lin, Ernesto L Pinheiro-Junior, Steve Peigneur, Dorothy C C Wai, Carlie Delaine, Andrew J Blyth, Briony E Forbes, Jan Tytgat and 2 more

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Toxins in disguise: Neuropeptide mimicry across animal venoms.General and comparative endocrinology · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Michela L MitchellMedicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052, Australia.ORCID 0000-0001-6331-534X
Mohammed Akhter HossainFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC 3010, Australia.
Feng LinFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC 3010, Australia.
Ernesto L Pinheiro-JuniorToxicology and Pharmacology, University of Leuven, O&N 2, Herestraat 49, P.O. Box 922, 3000 Leuven, Belgium.ORCID 0000-0001-6050-8285
Steve PeigneurToxicology and Pharmacology, University of Leuven, O&N 2, Herestraat 49, P.O. Box 922, 3000 Leuven, Belgium.
Dorothy C C WaiMedicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052, Australia.ORCID 0000-0002-3871-9980
Carlie DelaineFlinders Health and Medical Research Institute, Flinders University, Bedford Park, SA 5042, Australia.
Andrew J BlythFlinders Health and Medical Research Institute, Flinders University, Bedford Park, SA 5042, Australia.
Briony E ForbesFlinders Health and Medical Research Institute, Flinders University, Bedford Park, SA 5042, Australia.
Jan TytgatToxicology and Pharmacology, University of Leuven, O&N 2, Herestraat 49, P.O. Box 922, 3000 Leuven, Belgium.
John D WadeFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC 3010, Australia.ORCID 0000-0002-1352-6568
Raymond S NortonMedicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052, Australia.ORCID 0000-0001-8893-0584
Flinders University · AUKU Leuven · BEThe University of Melbourne · AUMonash University · AUQueensland Museum · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of insulin and insulin-like peptides (ILPs) in vertebrate animals is well studied. Numerous ILPs are also found in invertebrates, although there is uncertainty as to the function and role of many of these peptides. We have identified transcripts with similarity to the insulin family in the tentacle transcriptomes of the sea anemone

Indexed as

Amino Acid SequenceAnimalsCircular DichroismGene Expression ProfilingGene Expression RegulationInsulinPeptidesSea AnemonesInsulinPeptidescnidariainsulininvertebratesion channelOulactispeptide synthesis

Identifiers

PMID34944429
PMCPMC8698791
OpenAlexW3217652768

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.