Evidence map›Paper›PMID 34944415›Full record

ReviewBiomolecules2021

MicroRNAs Regulating Renin-Angiotensin-Aldosterone System, Sympathetic Nervous System and Left Ventricular Hypertrophy in Systemic Arterial Hypertension.

Alex Cleber Improta-Caria, Marcela Gordilho Aras, Luca Nascimento, Ricardo Augusto Leoni De Sousa, Roque Aras-Júnior, Bruno Solano de Freitas Souza

Open access · goldAbstract readReview
In one paragraph

Review in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 32 citations in OpenAlex.

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  11. MicroRNAs regulating signaling pathways in cardiac fibrosis: potential role of the exercise training.American journal of physiology. Heart and circulatory physiology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Alex Cleber Improta-CariaPost-Graduate Program in Medicine and Health, Faculty of Medicine, Federal University of Bahia, Salvador 40110-100, Brazil.
Marcela Gordilho ArasFaculty of Medicine, Federal University of Bahia, Salvador 40110-100, Brazil.
Luca NascimentoFaculty of Medicine, Federal University of Bahia, Salvador 40110-100, Brazil.
Ricardo Augusto Leoni De SousaNeuroscience and Exercise Group, UFVJM, Diamantina 39000-000, Brazil.ORCID 0000-0003-2622-032X
Roque Aras-JúniorPost-Graduate Program in Medicine and Health, Faculty of Medicine, Federal University of Bahia, Salvador 40110-100, Brazil.
Bruno Solano de Freitas SouzaCenter for Biotechnology and Cell Therapy, São Rafael Hospital, Salvador 41253-190, Brazil.
Universidade Federal da Bahia · BRD’Or Institute for Research and Education · BRUniversidade Federal dos Vales do Jequitinhonha e Mucuri · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs are small non-coding RNAs that regulate gene and protein expression. MicroRNAs also regulate several cellular processes such as proliferation, differentiation, cell cycle, apoptosis, among others. In this context, they play important roles in the human body and in the pathogenesis of diseases such as cancer, diabetes, obesity and hypertension. In hypertension, microRNAs act on the renin-angiotensin-aldosterone system, sympathetic nervous system and left ventricular hypertrophy, however the signaling pathways that interact in these processes and are regulated by microRNAs inducing hypertension and the worsening of the disease still need to be elucidated. Thus, the aim of this review is to analyze the pattern of expression of microRNAs in these processes and the possible associated signaling pathways.

Indexed as

Gene Expression RegulationHumansHypertensionHypertrophy, Left VentricularMicroRNAsRenin-Angiotensin SystemSignal TransductionSympathetic Nervous SystemMicroRNAshypertensionleft ventricular hypertrophymicroRNAsrenin–angiotensin–aldosterone systemsympathetic nervous system

Identifiers

PMID34944415
PMCPMC8698399
OpenAlexW3217448493

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.