Evidence map›Paper›PMID 34944397›Full record

ArticleBiomolecules2021

Near-Infrared Fluorescence Imaging of Carotid Plaques in an Atherosclerotic Murine Model.

Xiaotian Wu, Amy Daniel Ulumben, Steven Long, Wataru Katagiri, Moses Q Wilks, Hushan Yuan, Brian Cortese, Chengeng Yang, Satoshi Kashiwagi, Hak Soo Choi and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.1field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Xiaotian WuGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0003-3178-6256
Amy Daniel UlumbenGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Steven LongDepartment of Pathology, University of California, San Francisco, CA 94143, USA.
Wataru KatagiriGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Moses Q WilksGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Hushan YuanGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Brian CorteseGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0002-8523-8151
Chengeng YangGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Satoshi KashiwagiGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0001-8910-3257
Hak Soo ChoiGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0002-7982-6483
Marc D NormandinGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0003-1645-523X
Georges El FakhriGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Raiyan T ZamanGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Harvard University · USUniversity of California, San Francisco · US

Funding

Unified Joint Statistical Reconstruction of PET & MRP41EB022544 · NIBIB · YALE UNIVERSITY · PI Georges El Fakhri · 2017 to 2026
$14.8M
Postgraduate Training Program in Medical Imaging (PTPMI)T32EB013180 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Ciprian Catana, Pedram Heidari · 2011 to 2026
$3.7M
CaNCURE: Cancer Nanomedicine Co-ops For Undergraduate Research ExperiencesR25CA174650 · NCI · NORTHEASTERN UNIVERSITY · PI SRINIVAS SRIDHAR · 2014 to 2026
$3.4M
Nanochelation Therapies for Iron Overload DisordersR01HL143020 · NHLBI · UNIVERSITY OF MASSACHUSETTS LOWELL · PI CHOI, HAK SOO, KIM, JONGHAN · 2018 to 2021
$2.6M
PEG-like Multimodal Nanoprobes for Imaging Enhanced Permeability RetentionR01EB017699 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI NORMANDIN, MARC DAVID · 2014 to 2017
$1.6M
A Novel Intravascular CRI-PAT Imaging System to Characterize Vulnerable PlaqueR00HL127180 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ZAMAN, RAIYAN TRIPTI · 2019 to 2021
$745k
National Heart Lung and Blood Institute R00HL127180National Heart Lung and Blood Institute R01HL143020NCI NIH HHS R25CA174650NIBIB NIH HHS P41 EB022544NIBIB NIH HHS P41EB022544NIBIB NIH HHS R01EB017699NIBIB NIH HHS T32 EB013180NIBIB NIH HHS T32EB013180
6 · The paper itself

Abstract

Successful imaging of atherosclerosis, one of the leading global causes of death, is crucial for diagnosis and intervention. Near-infrared fluorescence (NIRF) imaging has been widely adopted along with multimodal/hybrid imaging systems for plaque detection. We evaluate two macrophage-targeting fluorescent tracers for NIRF imaging (TLR4-ZW800-1C and Feraheme-Alexa Fluor 750) in an atherosclerotic murine cohort, where the left carotid artery (LCA) is ligated to cause stenosis, and the right carotid artery (RCA) is used as a control. Imaging performed on dissected tissues revealed that both tracers had high uptake in the diseased vessel compared to the control, which was readily visible even at short exposure times. In addition, ZW800-1C's renal clearance ability and Feraheme's FDA approval puts these two tracers in line with other NIRF tracers such as ICG. Continued investigation with these tracers using intravascular NIRF imaging and larger animal models is warranted for clinical translation.

Indexed as

AnimalsCarotid Artery DiseasesDiet, High-FatDisease Models, AnimalFerrosoferric OxideHumansMacrophagesMaleMiceMolecular ImagingOptical ImagingPlaque, AtheroscleroticQuaternary Ammonium CompoundsSuccinimidesSulfonic AcidsToll-Like Receptor 4Alexa Fluor 750Ferrosoferric OxideQuaternary Ammonium CompoundsSuccinimidesSulfonic AcidsTlr4 protein, mouseToll-Like Receptor 4ZW800-1 compoundatherosclerosisFerahememacrophagesmolecular-targeted fluorescent tracersNIRFTLR4zwitterionic

Identifiers

PMID34944397
PMCPMC8698491
OpenAlexW3215768047

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.