Evidence map›Paper›PMID 34944396›Full record

ArticleBiomolecules2021

Expression of Estrogen Receptor Alpha and Evaluation of Histological Degeneration Scores in Fibroblasts of Hypertrophied Ligamentum Flavum: A Qualitative Study.

Christina C Westhoff, Christian-Dominik Peterlein, Hanna Daniel, Juergen R Paletta, Roland Moll, Annette Ramaswamy, Stefan Lakemeier

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 77% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Christina C WesthoffInstitute of Pathology, Philipps University, and University Hospital Giessen and Marburg, 35033 Marburg, Germany.ORCID 0000-0002-6812-3563
Christian-Dominik PeterleinCenter for Orthopedics and Trauma Surgery, Philipps University, and University Hospital Giessen and Marburg, 35033 Marburg, Germany.
Hanna DanielInstitute of Medical Biometry and Epidemiology, Philipps University, 35037 Marburg, Germany.
Juergen R PalettaCenter for Orthopedics and Trauma Surgery, Philipps University, and University Hospital Giessen and Marburg, 35033 Marburg, Germany.
Roland MollInstitute of Pathology, Philipps University, and University Hospital Giessen and Marburg, 35033 Marburg, Germany.
Annette RamaswamyInstitute of Pathology, Philipps University, and University Hospital Giessen and Marburg, 35033 Marburg, Germany.
Stefan LakemeierDepartment of Trauma Surgery, Orthopaedics and Plastic Surgery, University Medical Center Göttingen, 37075 Göttingen, Germany.
Universitätsklinikum Gießen und Marburg · DEPhilipps University of Marburg · DEUniversitätsmedizin Göttingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The most common spinal disorder in elderly is lumbar spinal stenosis (LSS), resulting partly from ligamentum flavum (LF) hypertrophy. Its pathophysiology is not completely understood. The present study wants to elucidate the role of estrogen receptor α (ER α) in fibroblasts of hypertrophied LF. LF samples of 38 patients with LSS were obtained during spinal decompression. Twelve LF samples from patients with disk herniation served as controls. Hematoxylin & Eosin (H&E) and Elastica stains and immunohistochemistry for ER α were performed. The proportions of fibrosis, loss and/or degeneration of elastic fibers and proliferation of collagen fibers were assessed according to the scores of Sairyo and Okuda. Group differences in the ER α and Sairyo and Okuda scores between patients and controls, male and female sex and absence and presence of additional orthopedic diagnoses were assessed with the Mann-Whitney

Indexed as

Up-RegulationAdultAgedAged, 80 and overDecompression, SurgicalEstrogen Receptor alphaEvaluation Studies as TopicFemaleFibroblastsHumansHypertrophyIntervertebral Disc DisplacementLigamentum FlavumMaleMiddle AgedOsteochondrosisESR1 protein, humanEstrogen Receptor alphacollagen fibersdegenerationelastic fibersestrogen receptor alphafibroblastsfibrosishypertrophyligamentum flavumlumbar spinal stenosisproliferation

Identifiers

PMID34944396
PMCPMC8698276
OpenAlexW3217262746

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.