Evidence map›Paper›PMID 34944324›Full record

ReviewAnimals : an open access journal from MDPI2021

Feline Coronavirus and Alpha-Herpesvirus Infections: Innate Immune Response and Immune Escape Mechanisms.

Paolo Capozza, Annamaria Pratelli, Michele Camero, Gianvito Lanave, Grazia Greco, Francesco Pellegrini, Maria Tempesta

Abstract readReview
In one paragraph

Review in Animals : an open access journal from MDPI, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Paolo CapozzaDepartment of Veterinary Medicine, University of Bari Aldo Moro, 70010 Valenzano, Italy.ORCID 0000-0001-5563-1131
Annamaria PratelliDepartment of Veterinary Medicine, University of Bari Aldo Moro, 70010 Valenzano, Italy.ORCID 0000-0001-6862-1792
Michele CameroDepartment of Veterinary Medicine, University of Bari Aldo Moro, 70010 Valenzano, Italy.
Gianvito LanaveDepartment of Veterinary Medicine, University of Bari Aldo Moro, 70010 Valenzano, Italy.ORCID 0000-0003-4614-677X
Grazia GrecoDepartment of Veterinary Medicine, University of Bari Aldo Moro, 70010 Valenzano, Italy.ORCID 0000-0002-4338-6746
Francesco PellegriniDepartment of Veterinary Medicine, University of Bari Aldo Moro, 70010 Valenzano, Italy.ORCID 0000-0003-0026-8472
Maria TempestaDepartment of Veterinary Medicine, University of Bari Aldo Moro, 70010 Valenzano, Italy.ORCID 0000-0003-4300-8822

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over time, feline viruses have acquired elaborateopportunistic properties, making their infections particularly difficult to prevent and treat. Feline coronavirus (FCoV) and feline herpesvirus-1 (FeHV-1), due to the involvement of host genetic factors and immune mechanisms in the development of the disease and more severe forms, are important examples of immune evasion of the host's innate immune response by feline viruses.It is widely accepted that the innate immune system, which providesan initial universal form of the mammalian host protection from infectious diseases without pre-exposure, plays an essential role in determining the outcome of viral infection.The main components of this immune systembranchare represented by the internal sensors of the host cells that are able to perceive the presence of viral component, including nucleic acids, to start and trigger the production of first type interferon and to activate the cytotoxicity by Natural Killercells, often exploited by viruses for immune evasion.In this brief review, we providea general overview of the principal tools of innate immunity, focusing on the immunologic escape implemented byFCoVand FeHV-1 duringinfection.

Indexed as

FCoVFeHV-1FIPVinnate immunity

Identifiers

PMID34944324
PMCPMC8698202

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.