Evidence map›Paper›PMID 34944086›Full record

ArticleCells2021

Adjunctive Thymosin Beta-4 Treatment Influences PMN Effector Cell Function during

Yuxin Wang, Thomas W Carion, Abdul Shukkur Ebrahim, Gabriel Sosne, Elizabeth A Berger

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yuxin WangDepartment of Ophthalmology, Visual and Anatomical Sciences, School of Medicine, Wayne State University, Detroit, MI 48201, USA.
Thomas W CarionDepartment of Ophthalmology, Visual and Anatomical Sciences, School of Medicine, Wayne State University, Detroit, MI 48201, USA.
Abdul Shukkur EbrahimDepartment of Ophthalmology, Visual and Anatomical Sciences, School of Medicine, Wayne State University, Detroit, MI 48201, USA.
Gabriel SosneDepartment of Ophthalmology, Visual and Anatomical Sciences, School of Medicine, Wayne State University, Detroit, MI 48201, USA.ORCID 0000-0002-4805-7327
Elizabeth A BergerDepartment of Ophthalmology, Visual and Anatomical Sciences, School of Medicine, Wayne State University, Detroit, MI 48201, USA.ORCID 0000-0001-5371-1170
Wayne State University · US

Funding

Tumor Biology and Microenvironment (Program 1)P30CA022453 · NCI · WAYNE STATE UNIVERSITY · PI Julie Lynn Boerner · 1985 to 2026
$68.4M
VISION RESEARCH--COREP30EY004068 · NEI · WAYNE STATE UNIVERSITY · PI LINDA D HAZLETT · 1985 to 2026
$13.2M
Thymosin beta-4 as an Adjunct Treatment for Bacterial KeratitisR01EY029836 · NEI · WAYNE STATE UNIVERSITY · PI BERGER, ELIZABETH · 2019 to 2023
$1.9M
VIP and Disease Resolution of Bacterial-Induced Ocular InfectionR01EY023226 · NEI · WAYNE STATE UNIVERSITY · PI BERGER, ELIZABETH · 2014 to 2017
$1.5M
NCI NIH HHS P30 CA022453NEI NIH HHS P30 EY004068NEI NIH HHS R01 EY023226NEI NIH HHS R01 EY029836
6 · The paper itself

Abstract

Previous work examining the therapeutic efficacy of adjunct thymosin beta 4 (Tβ4) to ciprofloxacin for ocular infectious disease has revealed markedly reduced inflammation (inflammatory mediators and innate immune cells) with increased activation of wound healing pathways. Understanding the therapeutic mechanisms of action have further revealed a synergistic effect with ciprofloxacin to enhance bacterial killing along with a regulatory influence over macrophage effector cell function. As a natural extension of the aforementioned work, the current study uses an experimental model of

Indexed as

AnimalsApoptosisBiomarkersCorneaDown-RegulationExtracellular TrapsFemaleLipid PeroxidationLipopolysaccharidesMiceMice, Inbred C57BLNeutrophilsOxidative StressPhenotypePseudomonas aeruginosaPseudomonas InfectionsBiomarkersLipopolysaccharidesSuperoxidesThymosinThymosin beta(4)apoptosisimmunoregulationkeratitisNETosisneutrophils/PMNROSTβ4

Identifiers

PMID34944086
PMCPMC8700181
OpenAlexW4200608133

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.