Evidence map›Paper›PMID 34944076›Full record

ReviewCells2021

Sulfated Hydrogels in Intervertebral Disc and Cartilage Research.

Emily Lazarus, Paola Bermudez-Lekerika, Daniel Farchione, Taylor Schofield, Sloan Howard, Iskender Mambetkadyrov, Mikkael Lamoca, Iris V Rivero, Benjamin Gantenbein, Christopher L Lewis and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Immuno-Modulatory Effects of Intervertebral Disc Cells.Frontiers in cell and developmental biology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Emily LazarusDepartment of Industrial and Systems Engineering, Rochester Institute of Technology, Rochester, NY 14632, USA.ORCID 0000-0002-7230-2011
Paola Bermudez-LekerikaTissue Engineering for Orthopaedics and Mechanobiology, Bone & Joint Program, Department for BioMedical Research (DBMR), Medical Faculty, University of Bern, CH-3008 Bern, Switzerland.ORCID 0000-0002-6858-8213
Daniel FarchioneInamori School of Engineering, Alfred University, Alfred, NY 14802, USA.
Taylor SchofieldDepartment of Biomedical Engineering, Rochester Institute of Technology, Rochester, NY 14632, USA.
Sloan HowardDepartment of Biomedical Engineering, Rochester Institute of Technology, Rochester, NY 14632, USA.
Iskender MambetkadyrovDepartment of Biomedical Engineering, Rochester Institute of Technology, Rochester, NY 14632, USA.
Mikkael LamocaDepartment of Biomedical Engineering, Rochester Institute of Technology, Rochester, NY 14632, USA.ORCID 0000-0002-9218-3523
Iris V RiveroDepartment of Industrial and Systems Engineering, Rochester Institute of Technology, Rochester, NY 14632, USA.ORCID 0000-0001-5542-0836
Benjamin GantenbeinTissue Engineering for Orthopaedics and Mechanobiology, Bone & Joint Program, Department for BioMedical Research (DBMR), Medical Faculty, University of Bern, CH-3008 Bern, Switzerland.ORCID 0000-0002-9005-0655
Christopher L LewisDepartment of Manufacturing and Mechanical Engineering Technology, Rochester Institute of Technology, Rochester, NY 14632, USA.
Karin Wuertz-KozakDepartment of Biomedical Engineering, Rochester Institute of Technology, Rochester, NY 14632, USA.ORCID 0000-0002-3281-4629

Funding

Marie Skłodowska Curie International Training Network (ITN) "disc4all" 955735
6 · The paper itself

Abstract

Hydrogels are commonly used for the 3D culture of musculoskeletal cells. Sulfated hydrogels, which have seen a growing interest over the past years, provide a microenvironment that help maintain the phenotype of chondrocytes and chondrocyte-like cells and can be used for sustained delivery of growth factors and other drugs. Sulfated hydrogels are hence valuable tools to improve cartilage and intervertebral disc tissue engineering. To further advance the utilization of these hydrogels, we identify and summarize the current knowledge about different sulfated hydrogels, highlight their beneficial effects in cartilage and disc research, and review the biofabrication processes most suitable to secure best quality assurance through deposition fidelity, repeatability, and attainment of biocompatible morphologies.

Indexed as

ResearchAnimalsCartilageHumansHydrogelsIntervertebral DiscSulfatesTissue EngineeringHydrogelsSulfateschondrogenic phenotypechondroitin sulfateheparan sulfatesulfated alginatesulfated hyaluronansustained release of growth factors

Identifiers

PMID34944076
PMCPMC8700363

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.