Evidence map›Paper›PMID 34944043›Full record

ArticleCells2021

Immunomodulatory Properties of Polysaccharides from the Coral

Oleg V Chernikov, Hsiao-Wen Chiu, Lan-Hui Li, Maxim S Kokoulin, Valentina I Molchanova, Hsien-Ta Hsu, Chen-Lung Ho, Kuo-Feng Hua

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

  1. Nanomaterials (Basel, Switzerland) · 2025
    Article
  2. Immunomodulatory Effects ofAntioxidants (Basel, Switzerland) · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. The leaves of the seasoning plantFrontiers in nutrition · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Oleg V ChernikovG.B. Elyakov Pacific Institute of Bioorganic Chemistry FEB RAS, 690022 Vladivostok, Russia.ORCID 0000-0002-3076-3637
Hsiao-Wen ChiuDepartment of Biotechnology and Animal Science, National Ilan University, Ilan 260007, Taiwan.
Lan-Hui LiDepartment of Laboratory Medicine, Linsen, Chinese Medicine and Kunming Branch, Taipei City Hospital, Taipei 108, Taiwan.
Maxim S KokoulinG.B. Elyakov Pacific Institute of Bioorganic Chemistry FEB RAS, 690022 Vladivostok, Russia.ORCID 0000-0003-2245-6802
Valentina I MolchanovaG.B. Elyakov Pacific Institute of Bioorganic Chemistry FEB RAS, 690022 Vladivostok, Russia.
Hsien-Ta HsuDivision of Neurosurgery, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 231, Taiwan.
Chen-Lung HoDivision of Wood Cellulose, Taiwan Forestry Research Institute, Taipei 100051, Taiwan.
Kuo-Feng HuaDepartment of Biotechnology and Animal Science, National Ilan University, Ilan 260007, Taiwan.
Pacific Institute of Bioorganic Chemistry. GB Elyakova Far Eastern Branch of the Russian Academy of Sciences · RUTri-Service General Hospital · TWNational Ilan University · TWTaiwan Forestry Research Institute · TWTzu Chi University · TW

Funding

Ministry of Science and Technology of Taiwan MOST 108-2923-B-197-001-MY3Ministry of Science and Technology of Taiwan MOST 110-2923-B-197-001-MY3RFBR and MOST 21-54-52005
6 · The paper itself

Abstract

Polysaccharides from marine organisms produce an important regulatory effect on the mammalian immune system. In this study, the immunomodulatory properties of a polysaccharide that was isolated from the coral

Indexed as

AnimalsAnthozoaCyclooxygenase 2CytokinesEscherichia coliHumansImmunologic FactorsInflammation MediatorsInterleukin-6LipopolysaccharidesMacrophage ActivationMacrophagesMiceMitogen-Activated Protein KinasesNF-kappa BPhagocytosisCyclooxygenase 2CytokinesImmunologic FactorsInflammation MediatorsInterleukin-6LipopolysaccharidesMitogen-Activated Protein KinasesNF-kappa BPolysaccharidesProtein Kinase C-alphaProtein Kinase C-deltaReactive Oxygen SpeciesToll-Like Receptor 4Tumor Necrosis Factor-alphaimmune modulationmacrophagespolysaccharidePseudopterogorgia americana

Identifiers

PMID34944043
PMCPMC8700520
OpenAlexW4200386024

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.