MUT-7 Provides Molecular Insight into the Werner Syndrome Exonuclease.

Tsung-Yuan Hsu, Ling-Nung Hsu, Shih-Yu Chen, Bi-Tzen Juang

Open access · goldAbstract readReview

In one paragraph

Review in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.1field-weighted citation impact, top 54% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Tsung-Yuan HsuDepartment of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu 300, Taiwan.

Ling-Nung HsuOccupational Safety and Health Office, Fu Jen Catholic University Hospital, New Taipei City 243, Taiwan.

Shih-Yu ChenInstitute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan.

Bi-Tzen JuangDepartment of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu 300, Taiwan.ORCID 0000-0003-1210-0992

National Yang Ming Chiao Tung University · TWFu Jen Catholic University · TWInstitute of Biomedical Sciences, Academia Sinica · TW

Funding

NIH HHS 5R01DC005991-14

6 · The paper itself

Abstract

Werner syndrome (WS) is a rare recessive genetic disease characterized by premature aging. Individuals with this disorder develop normally during childhood, but their physiological conditions exacerbate the aging process in late adolescence. WS is caused by mutation of the human WS gene (

Indexed as

Aging, PrematureAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsDNA HelicasesExoribonucleasesHeterochromatinHumansMutationRNA, Small InterferingWerner SyndromeCaenorhabditis elegans ProteinsDNA HelicasesExoribonucleasesHeterochromatinMUT-7 protein, C elegansRNA, Small InterferingWRN-1 protein, C elegans3′-5′ exonucleasesC. elegans neuronal plasticityC. elegans WRN-1 (CeWRN-1)MUT-7small interfering RNAWerner syndrome

Identifiers

PMID34943966

DOI10.3390/cells10123457

PMCPMC8700014

OpenAlexW4200455488

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.