Evidence map›Paper›PMID 34943901›Full record

ArticleCells2021

The GRP94 Inhibitor PU-WS13 Decreases M2-like Macrophages in Murine TNBC Tumors: A Pharmaco-Imaging Study with

Alexanne Bouchard, Hugo Sikner, Valentin Baverel, Anaïs-Rachel Garnier, Marie Monterrat, Mathieu Moreau, Emeric Limagne, Carmen Garrido, Evelyne Kohli, Bertrand Collin and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. ATM interaction with GRP94 modulates oncogenic receptor expression and signaling and microglial activation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Hsp90Pharmaceuticals (Basel, Switzerland) · 2025
    Review
  6. Extrinsic and Cell-Intrinsic Stress in the Immune Tumor Micro-Environment.International journal of molecular sciences · 2024
    Review
  7. Article
  8. Polygonatum sibiricum component liquiritigenin restrains breast cancer cell invasion and migration by inhibiting HSP90 and chaperone-mediated autophagy.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2024
    Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Alexanne BouchardCentre George-François Leclerc, Service de Médecine Nucléaire, Plateforme d'imagerie et de Radiothérapie Précliniques, 21000 Dijon, France.
Hugo SiknerCentre George-François Leclerc, Service de Médecine Nucléaire, Plateforme d'imagerie et de Radiothérapie Précliniques, 21000 Dijon, France.
Valentin BaverelUMR INSERM/uB/AGROSUP 1231, Team 3 HSP-Pathies, Labellisée Ligue National Contre le Cancer and Laboratoire d'Excellence LipSTIC, Université Bourgogne Franche-Comté, 21000 Dijon, France.
Anaïs-Rachel GarnierCentre George-François Leclerc, Service de Médecine Nucléaire, Plateforme d'imagerie et de Radiothérapie Précliniques, 21000 Dijon, France.
Marie MonterratCentre George-François Leclerc, Service de Médecine Nucléaire, Plateforme d'imagerie et de Radiothérapie Précliniques, 21000 Dijon, France.
Mathieu MoreauInstitut de Chimie Moléculaire de l'Université de Bourgogne, UMR CNRS/uB 6302, Université de Bourgogne Franche-Comté, 21000 Dijon, France.
Emeric LimagneCentre George-François Leclerc, Plateforme de Transfert en Biologie Cancérologique, 21000 Dijon, France.
Carmen GarridoUMR INSERM/uB/AGROSUP 1231, Team 3 HSP-Pathies, Labellisée Ligue National Contre le Cancer and Laboratoire d'Excellence LipSTIC, Université Bourgogne Franche-Comté, 21000 Dijon, France.
Evelyne KohliUMR INSERM/uB/AGROSUP 1231, Team 3 HSP-Pathies, Labellisée Ligue National Contre le Cancer and Laboratoire d'Excellence LipSTIC, Université Bourgogne Franche-Comté, 21000 Dijon, France.
Bertrand CollinCentre George-François Leclerc, Service de Médecine Nucléaire, Plateforme d'imagerie et de Radiothérapie Précliniques, 21000 Dijon, France.
Pierre-Simon BellayeCentre George-François Leclerc, Service de Médecine Nucléaire, Plateforme d'imagerie et de Radiothérapie Précliniques, 21000 Dijon, France.
Centre Georges François Leclerc · FRInserm · FRCentre National de la Recherche Scientifique · FRInstitut de Chimie · FRLa Ligue Contre le Cancer · FRUniversité Bourgogne Franche-Comté · FR

Funding

Agence Nationale de la Recherche ANR-10-EQPX-05-01Agence Nationale de la Recherche ANR- 11-LABX-0021Agence Nationale de la Recherche ANR-15-IDEX-0003
6 · The paper itself

Abstract

Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancers and is not eligible for hormone and anti-HER2 therapies. Identifying therapeutic targets and associated biomarkers in TNBC is a clinical challenge to improve patients' outcome and management. High infiltration of CD206

Indexed as

AnimalsCD8-Positive T-LymphocytesCell LineageCell Line, TumorDextransDisease Models, AnimalGene Expression Regulation, NeoplasticHumansMacrophagesMannansMannose ReceptorMembrane GlycoproteinsMiceSignal TransductionTechnetium Tc 99m PentetateTomography, Emission-Computed, Single-PhotonDextransendoplasminMannansMannose ReceptorMembrane Glycoproteinstechnetium-diethylenetriaminepentaacetic acid-mannosyl-dextranTechnetium Tc 99m PentetatebiomarkerCD206GRP94M2-like macrophagesPU-WS13SPECT imagingTilmanocepttriple-negative breast cancer

Identifiers

PMID34943901
PMCPMC8699502
OpenAlexW3214855634

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.