Evidence map›Paper›PMID 34943872›Full record

ArticleCells2021

Targeting CAMKK2 and SOC Channels as a Novel Therapeutic Approach for Sensitizing Acute Promyelocytic Leukemia Cells to All-Trans Retinoic Acid.

Faten Merhi, Karla Alvarez-Valadez, Jenifer Trepiana, Claire Lescoat, Alexis Groppi, Jean-William Dupuy, Pierre Soubeyran, Guido Kroemer, Pierre Vacher, Mojgan Djavaheri-Mergny

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. STIM1 in tumor cell death: angel or devil?Cell death discovery · 2023
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Faten MerhiInstitut Bergonié, INSERM U1218, University of Bordeaux, 33000 Bordeaux, France.
Karla Alvarez-ValadezCentre de Recherche des Cordeliers, INSERM UMRS 1138, Sorbonne Université, Université de Paris, Équipe 11 labellisée par la Ligue Contre le Cancer, 75006 Paris, France.
Jenifer TrepianaInstitut Bergonié, INSERM U1218, University of Bordeaux, 33000 Bordeaux, France.ORCID 0000-0003-1316-5923
Claire LescoatCentre de Bioinformatique de Bordeaux (CBiB), University of Bordeaux, 33076 Bordeaux, France.
Alexis GroppiCentre de Bioinformatique de Bordeaux (CBiB), University of Bordeaux, 33076 Bordeaux, France.ORCID 0000-0002-3341-8281
Jean-William DupuyUniversity of Bordeaux, Plateforme Protéome, 33076 Bordeaux, France.ORCID 0000-0002-2448-4797
Pierre SoubeyranInstitut Bergonié, INSERM U1218, University of Bordeaux, 33000 Bordeaux, France.ORCID 0000-0003-3244-7299
Guido KroemerCentre de Recherche des Cordeliers, INSERM UMRS 1138, Sorbonne Université, Université de Paris, Équipe 11 labellisée par la Ligue Contre le Cancer, 75006 Paris, France.ORCID 0000-0002-9334-4405
Pierre VacherPRASE, Platform of Research and Analysis in Environmental Sciences, Doctoral School of Sciences and Technologies, Lebanese University, Hadat Campus, Beirut 1003, Lebanon.ORCID 0000-0003-3503-7981
Mojgan Djavaheri-MergnyCentre de Recherche des Cordeliers, INSERM UMRS 1138, Sorbonne Université, Université de Paris, Équipe 11 labellisée par la Ligue Contre le Cancer, 75006 Paris, France.ORCID 0000-0003-4893-6505
Université de Bordeaux · FRInserm · FRCentre National de la Recherche Scientifique · FRLebanese University · LB

Funding

F.M. was supported by a post-doctoral fellowship from the "Aquitaine Regional Council "(to MDM). K.A-V is supported by the Mexican National Council of Science and Technology (CONACYT, funding #757821). This work was supported by funds from the Institut N ANR-18-IDEX-0001.
6 · The paper itself

Abstract

Calcium ions (Ca

Indexed as

Adenylate KinaseAutophagyCalciumCalcium-Calmodulin-Dependent Protein Kinase KinaseCalcium ChannelsCell DifferentiationCell Line, TumorDrug Resistance, NeoplasmEnzyme ActivationGranulocytesHumansLeukemia, Promyelocytic, AcuteTretinoinUp-RegulationAdenylate KinaseCalciumCalcium-Calmodulin-Dependent Protein Kinase KinaseCalcium ChannelsCAMKK2 protein, humanTretinoinAMPKautophagycancercell deathdifferentiationORAI1resistance to therapySTIM1therapy

Identifiers

PMID34943872
PMCPMC8699360
OpenAlexW3216888579

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.