Evidence map›Paper›PMID 34943853›Full record

ArticleCells2021

C-C Motif Chemokine Ligand-17 as a Novel Biomarker and Regulator of Epithelial Mesenchymal Transition in Renal Fibrogenesis.

Yi-Hsien Hsieh, Wen-Chien Wang, Tung-Wei Hung, Chu-Che Lee, Jen-Pi Tsai

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Yi-Hsien HsiehInstitute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.ORCID 0000-0003-4942-1888
Wen-Chien WangInstitute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.ORCID 0000-0002-5150-9670
Tung-Wei HungSchool of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.
Chu-Che LeeDepartment of Medicine Research, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi 62247, Taiwan.
Jen-Pi TsaiSchool of Medicine, Tzu Chi University, Hualien 97004, Taiwan.ORCID 0000-0001-9405-8649
Chung Shan Medical University Hospital · TWChung Shan Medical University · TWTzu Chi University · TW

Funding

Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation DTCRD108(2)-E-08
6 · The paper itself

Abstract

CCL17, a chemotactic cytokine produced by macrophages, is known to promote inflammatory and fibrotic effects in multiple organs, but its role in mediating renal fibrosis is unclear. In our study cohort of 234 chronic kidney disease (CKD) patients and 65 healthy controls, human cytokine array analysis revealed elevated CCL17 expression in CKD that correlated negatively with renal function. The area under the receiver operating characteristic curve of CCL17 to predict the development of CKD stages 3b-5 was 0.644 (

Indexed as

BiomarkersCase-Control StudiesCell CycleCell MovementCell SurvivalChemokine CCL17Epithelial-Mesenchymal TransitionFibrosisGlomerular Filtration RateHumansKidneyModels, BiologicalRenal Insufficiency, ChronicRNA, MessengerUp-RegulationUreteral ObstructionBiomarkersCCL17 protein, humanChemokine CCL17RNA, MessengerCCL17chronic kidney diseaseepithelial mesenchymal transitionunilateral urethral obstruction

Identifiers

PMID34943853
PMCPMC8699042
OpenAlexW3216738930

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.